Molecular structure of (R)-(+)-HA-966, CAS Number: 123931-04-4
(R)-(+)-HA-966 (CAS 123931-04-4)
Alternate Names:
R(+)-3-Amino-1-hydroxy-2-pyrrolidinone
Application:
(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor
CAS Number:
123931-04-4
Purity:
≥98%
Molecular Weight:
116.12
Molecular Formula:
C4H8N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-(+)-HA-966 has been reported to be a cell permeable antagonist and a partial agonist at the glycine site of the NMDA receptor.
(R)-(+)-HA-966 (CAS 123931-04-4) References
- Biochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats. | Morrow, BA., et al. 1999. Psychopharmacology (Berl). 143: 227-34. PMID: 10353424
- NMDA receptor antagonists acting at the glycineB site in rat models for antipsychotic-like activity. | Karcz-Kubicha, M., et al. 1999. J Neural Transm (Vienna). 106: 1189-204. PMID: 10651113
- Divergent effects of putative anxiolytics on stress-induced fos expression in the mesoprefrontal system of the rat. | Morrow, BA., et al. 2000. Synapse. 36: 143-54. PMID: 10767061
- Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents. | Dunn, RW., et al. 1992. Eur J Pharmacol. 214: 207-14. PMID: 1355434
- R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. | Hutson, PH., et al. 1991. Br J Pharmacol. 103: 2037-44. PMID: 1655150
- The discriminative stimulus properties of (+)-HA-966, an antagonist at the glycine/N-methyl-D-aspartate receptor. | Singh, L., et al. 1990. Eur J Pharmacol. 186: 129-32. PMID: 2149338
- R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures. | Morrow, BA., et al. 1995. Brain Res. 673: 165-9. PMID: 7757472
- Glutamate antagonists have different effects on spontaneous locomotor activity in rats. | Danysz, W., et al. 1994. Pharmacol Biochem Behav. 48: 111-8. PMID: 8029281
- Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats. | Löscher, W., et al. 1994. Br J Pharmacol. 112: 97-106. PMID: 8032669
- The glycine/NMDA receptor ligand (+)-HA-966 but not D-cycloserine has potent antidystonic efficacy in a genetic animal model of dystonia. | Löscher, W. and Richter, A. 1993. Eur J Pharmacol. 239: 245-7. PMID: 8223902
- The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents. | Bristow, LJ., et al. 1993. Br J Pharmacol. 108: 1156-63. PMID: 8485625
- Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: reversal by glycine/N-methyl-D-aspartate antagonist co-treatment. | Morrow, BA., et al. 1995. Neuroscience. 69: 233-40. PMID: 8637621
- Neuroprotective effects of the strychnine-insensitive glycine site NMDA antagonist (R)-HA-966 in an experimental model of Parkinson's disease. | Kanthasamy, AG., et al. 1997. Brain Res. 759: 1-8. PMID: 9219856
- (S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. | Morrow, BA., et al. 1997. J Pharmacol Exp Ther. 283: 712-21. PMID: 9353390
- Anxiolytic activity of glycine-B antagonists and partial agonists--no relation to intrinsic activity in the patch clamp. | Karcz-Kubicha, M., et al. 1997. Neuropharmacology. 36: 1355-67. PMID: 9423923
Inhibitor of:
NMDA.Activator of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-(+)-HA-966, 5 mg | sc-361303 | 5 mg | $95.00 |