Molecular structure of (R)-(+)-Carvedilol, CAS Number: 95093-99-5
(R)-(+)-Carvedilol (CAS 95093-99-5)
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Alternate Names:
(+)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; (+)-Carvedilol; (R)-Carvedilol
CAS Number:
95093-99-5
Molecular Weight:
406.47
Molecular Formula:
C24H26N2O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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(R)-(+)-Carvedilol, the optically active isomer of Carvedilol, exhibits nonselective β-adrenergic blocking activity along with concurrent α1-blocking activity. (R)-(+)-Carvedilol has been extensively studied across various scientific research applications. It has been employed to explore cardiac myocyte apoptosis, hypertension, cardioprotection, and the effects of β-blockers on the autonomic nervous system. The mechanism of action of (R)-(+)-Carvedilol involves the blockade of β-adrenergic receptors. These receptors are present in the heart, lungs, and other organs, and are responsible for the release of catecholamines like epinephrine and norepinephrine. By inhibiting the function of these receptors, (R)-(+)-Carvedilol reduces the release of these catecholamin
(R)-(+)-Carvedilol (CAS 95093-99-5) References
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- Effect of fluoxetine on carvedilol pharmacokinetics, CYP2D6 activity, and autonomic balance in heart failure patients. | Graff, DW., et al. 2001. J Clin Pharmacol. 41: 97-106. PMID: 11225566
- Development of a capillary electrophoresis assay for the determination of carvedilol enantiomers in serum using cyclodextrins. | Clohs, L. and McErlane, KM. 2001. J Pharm Biomed Anal. 24: 545-54. PMID: 11272310
- Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property. | Yuan, Z., et al. 2004. Am J Physiol Heart Circ Physiol. 286: H83-90. PMID: 14684360
- Enantioselective and highly sensitive determination of carvedilol in human plasma and whole blood after administration of the racemate using normal-phase high-performance liquid chromatography. | Saito, M., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 843: 73-7. PMID: 16784906
- Stereoselective metabolism of carvedilol in the rat. Use of enantiomerically radiolabeled pseudoracemates. | Fujimaki, M., et al. 1991. Drug Metab Dispos. 19: 749-53. PMID: 1680650
- Pharmacokinetic properties of a new controlled-release formulation of carvedilol. | Tenero, DM., et al. 2006. Am J Cardiol. 98: 5L-16L. PMID: 17023227
- Stereoselective analysis of carvedilol in human plasma and urine using HPLC after chiral derivatization. | Peccinini, RG., et al. 2008. Biopharm Drug Dispos. 29: 280-8. PMID: 18551504
- General pharmacological profiles of the new beta-adrenoceptor antagonist carvedilol. | Hirohashi, M., et al. 1990. Arzneimittelforschung. 40: 735-46. PMID: 1977393
- Identification of two major biliary metabolites of carvedilol in rats. | Fujimaki, M. and Hakusui, H. 1990. Xenobiotica. 20: 1025-34. PMID: 2082592
- Carvedilol in the treatment of portal hypertension. | Al-Ghamdi, H. 2011. Saudi J Gastroenterol. 17: 155-8. PMID: 21372358
- Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection. | Silva, RA., et al. 2012. J Pharm Biomed Anal. 70: 631-5. PMID: 22809671
- Determination of Carvedilol Enantiomers in Pharmaceutical Dosages by SBSE-HPLC Based on Diastereomer Formation. | Taraji, M., et al. 2015. J Chromatogr Sci. 53: 1316-21. PMID: 25700550
- Pharmacodynamic profile of carvedilol. | van Zwieten, PA. 1993. Cardiology. 82 Suppl 3: 19-23. PMID: 8106159
- In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol. | Oldham, HG. and Clarke, SE. 1997. Drug Metab Dispos. 25: 970-7. PMID: 9280405
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-(+)-Carvedilol, 2 mg | sc-212656A | 2 mg | $281.00 | |||
(R)-(+)-Carvedilol, 5 mg | sc-212656 | 5 mg | $322.00 | |||
(R)-(+)-Carvedilol, 10 mg | sc-212656B | 10 mg | $650.00 | |||
(R)-(+)-Carvedilol, 25 mg | sc-212656C | 25 mg | $1441.00 | |||
(R)-(+)-Carvedilol, 50 mg | sc-212656D | 50 mg | $2507.00 |