(R)-Norfluoxetine (CAS 130194-43-3)
QUICK LINKS
(R)-Norfluoxetine is a selective serotonin reuptake inhibitor that functions by inhibiting the reuptake of serotonin at the presynaptic membrane, leading to increased extracellular levels of serotonin in the brain. (R)-Norfluoxetine modulates the activity of serotonin, a neurotransmitter involved in mood regulation, by preventing its reabsorption into the presynaptic cell after it is released into the synaptic cleft. (R)-Norfluoxetine prolongs the action of serotonin and enhances its neurotransmission, which may have implications for the regulation of mood, emotion, and behavior. (R)-Norfluoxetine binds to the serotonin transporter protein, blocking its ability to transport serotonin back into the presynaptic neuron. This mechanism of action results in an accumulation of serotonin in the synaptic cleft, leading to prolonged signaling and potential downstream effects on neuronal function.
(R)-Norfluoxetine (CAS 130194-43-3) References
- Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine. | Ring, BJ., et al. 2001. J Pharmacol Exp Ther. 297: 1044-50. PMID: 11356927
- Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical response. | Jannuzzi, G., et al. 2002. Ther Drug Monit. 24: 616-27. PMID: 12352933
- R-fluoxetine increases extracellular DA, NE, as well as 5-HT in rat prefrontal cortex and hypothalamus: an in vivo microdialysis and receptor binding study. | Koch, S., et al. 2002. Neuropsychopharmacology. 27: 949-59. PMID: 12464452
- Direct stereoselective assay of fluoxetine and norfluoxetine enantiomers in human plasma or serum by two-dimensional gas-liquid chromatography with nitrogen-phosphorus selective detection. | Ulrich, S. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 783: 481-90. PMID: 12482491
- In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. | Pinna, G., et al. 2003. Proc Natl Acad Sci U S A. 100: 2035-40. PMID: 12571361
- Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo. | Fuller, RW., et al. 1992. Neuropharmacology. 31: 997-1000. PMID: 1279447
- Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. | Matsumoto, K., et al. 2005. Stress. 8: 85-93. PMID: 16019600
- SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. | Pinna, G., et al. 2009. Curr Opin Pharmacol. 9: 24-30. PMID: 19157982
- A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS). | Chow, TW., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 349-58. PMID: 21242112
- Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems. | Lutz, JD., et al. 2013. Drug Metab Dispos. 41: 2056-65. PMID: 23785064
- Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450. | Stevens, JC. and Wrighton, SA. 1993. J Pharmacol Exp Ther. 266: 964-71. PMID: 8355218
- Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. | Wong, DT., et al. 1993. Neuropsychopharmacology. 8: 337-44. PMID: 8512621
- Drug concentrations in mouse brain at pharmacologically active doses of fluoxetine enantiomers. | Fuller, RW. and Snoddy, HD. 1993. Biochem Pharmacol. 45: 2355-8. PMID: 8517878
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-Norfluoxetine, 2.5 mg | sc-208248 | 2.5 mg | $311.00 |