Molecular structure of (R)-Naproxen Acyl-β-D-glucuronide, CAS Number: 112828-15-6
(R)-Naproxen Acyl-β-D-glucuronide (CAS 112828-15-6)
Alternate Names:
1-[(αR)-6-Methoxy-α-methyl-2-naphthaleneacetate] β-D-Glucopyranuronic Acid; (R)-Naproxen Glucuronide
Application:
(R)-Naproxen Acyl-β-D-glucuronide is a metabolite of the Cox inhibitor naproxen
CAS Number:
112828-15-6
Molecular Weight:
406.38
Molecular Formula:
C20H22O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-Naproxen acyl-β-D-glucuronide is a metabolite derived from naproxen.The glucuronidation process of naproxen, a prominent metabolic pathway, leads to the creation of (R)-Naproxen acyl-β-D-glucuronide. it is believed to exert its anti-inflammatory and analgesic effects through the inhibition of cyclooxygenase (COX) enzymes. These enzymes play a vital role in the production of prostaglandins.
(R)-Naproxen Acyl-β-D-glucuronide (CAS 112828-15-6) References
- Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac. | King, C., et al. 2001. Toxicol Sci. 61: 49-53. PMID: 11294973
- Determination of naproxen in human urine by solid-phase microextraction coupled to liquid chromatography. | Aresta, A., et al. 2005. J Pharm Biomed Anal. 39: 643-7. PMID: 15905065
- Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4. | Kawase, A., et al. 2016. J Pharmacol Exp Ther. 356: 366-74. PMID: 26659924
- Inhibition of Methotrexate Uptake via Organic Anion Transporters OAT1 and OAT3 by Glucuronides of Nonsteroidal Anti-inflammatory Drugs. | Iwaki, M., et al. 2017. Biol Pharm Bull. 40: 926-931. PMID: 28566636
- NSAIDs: an overview. | Boynton, CS., et al. 1988. J Clin Pharmacol. 28: 512-7. PMID: 3047176
- Stereoselective glucuronidation of (R)- and (S)-naproxen by recombinant rat phenol UDP-glucuronosyltransferase (UGT1A1) and its human orthologue. | el Mouelhi, M., et al. 1993. Biochem Pharmacol. 46: 1298-300. PMID: 8216382
- Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. | Jin, C., et al. 1993. J Pharmacol Exp Ther. 264: 475-9. PMID: 8423545
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-Naproxen Acyl-β-D-glucuronide, 1 mg | sc-222236 | 1 mg | $439.00 |