(R)-Naproxen Acyl-beta-D-glucuronide CAS: 112828-15-6
MF: C20H22O9
MW: 406.38
A metabolite of the Cox inhibitor naproxen.

(R)-Naproxen Acyl-β-D-glucuronide (CAS 112828-15-6)

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Application: (R)-Naproxen Acyl-β-D-glucuronide is a metabolite of the Cox inhibitor naproxen
CAS Number: 112828-15-6
Molecular Weight: 406.38
Molecular Formula: C20H22O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(R)-Naproxen Acyl-β-D-glucuronide is a metabolite of naproxen (sc-200506), a potent inhibitor of Cox-1 and -2.


References

1. Boynton, C S., et al., 1988. NSAIDs: an overview. Journal of clinical pharmacology. 28(6): 512-7. PMID: 3047176
2. Jin, C., et al., 1993. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. The Journal of pharmacology and experimental therapeutics. 264(1): 475-9. PMID: 8423545
3. King, C., et al., 2001. Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac. Toxicological sciences : an official journal of the Society of Toxicology. 61(1): 49-53. PMID: 11294973
4. Aresta, Antonella., et al., 2005. Determination of naproxen in human urine by solid-phase microextraction coupled to liquid chromatography. Journal of pharmaceutical and biomedical analysis. 39(3-4): 643-7. PMID: 15905065

Physical State :
Solid
Solubility :
Soluble in methanol.
Storage :
Store at -20° C
Melting Point :
128-130° C
Boiling Point :
~642.5° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
181715
MDL Number :
MFCD00871176
SMILES :
C[[email protected]@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O[[email protected]]3[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O3)C(=O)O)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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