Molecular structure of (R)-Naproxen, CAS Number: 23979-41-1
(R)-Naproxen (CAS 23979-41-1)
CAS Number:
23979-41-1
Molecular Weight:
230.26
Molecular Formula:
C14H14O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-Naproxen is a nonsteroidal anti-inflammatory compound that inhibits the activity of the enzyme cyclooxygenase.(R)-Naproxen prevents the conversion of arachidonic acid to prostaglandin precursors, thereby reducing the production of prostaglandins. (R)-Naproxen′s mode of action involves reversible inhibition of the COX enzymes, which are responsible for the production of prostaglandins from arachidonic acid. This inhibition occurs through the binding of the compound to the active site of the enzyme, preventing the conversion of arachidonic acid to prostaglandins.
(R)-Naproxen (CAS 23979-41-1) References
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- On the enantioselectivity of the mass transfer kinetics and the adsorption equilibrium of Naproxen on the chiral stationary phase (R,R)-Whelk-O1 under reversed-phase conditions. | Asnin, L., et al. 2010. J Chromatogr A. 1217: 1320-31. PMID: 20079905
- Enantiospecific fate of ibuprofen, ketoprofen and naproxen in a laboratory-scale membrane bioreactor. | Hashim, NH., et al. 2011. Water Res. 45: 6249-58. PMID: 21974875
- (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. | Duggan, KC., et al. 2011. Nat Chem Biol. 7: 803-9. PMID: 22053353
- The adsorption of naproxen enantiomers on the chiral stationary phase (R,R)-whelk-O1 under supercritical fluid conditions. | Kamarei, F., et al. 2014. J Chromatogr A. 1345: 200-6. PMID: 24792696
- Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. | Oprea, TI., et al. 2015. PLoS One. 10: e0142182. PMID: 26558612
- Effect of R and S enantiomers of naproxen on aggregation and thromboxane production in human platelets. | Kean, WF., et al. 1989. J Pharm Sci. 78: 324-7. PMID: 2724096
- Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. | Adeniji, A., et al. 2016. J Med Chem. 59: 7431-44. PMID: 27486833
- Chiral recognition of naproxen enantiomers based on fluorescence quenching of bovine serum albumin-stabilized gold nanoclusters. | Jafari, M., et al. 2017. Spectrochim Acta A Mol Biomol Spectrosc. 185: 77-84. PMID: 28549294
- Solvent-dependent inversion of circular dichroism signal in naproxen: An unusual effect! | Ximenes, VF., et al. 2018. Chirality. 30: 1049-1053. PMID: 29969152
- A Chirality/Light Dual-Responsive Calixarene-Functionalized Gold Surface for the Separation of Naproxen Enantiomers. | Xu, P., et al. 2019. Chempluschem. 84: 907-912. PMID: 31943981
- Nonsteroidal antiinflammatory agents. I. 6-substituted 2-naphthylacetic acids. | Harrison, IT., et al. 1970. J Med Chem. 13: 203-5. PMID: 5418489
- Stereoselective glucuronidation of (R)- and (S)-naproxen by recombinant rat phenol UDP-glucuronosyltransferase (UGT1A1) and its human orthologue. | el Mouelhi, M., et al. 1993. Biochem Pharmacol. 46: 1298-300. PMID: 8216382
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-Naproxen, 1 g | sc-358531 | 1 g | $342.00 | |||
(R)-Naproxen, 5 g | sc-358531A | 5 g | $600.00 |