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(R)-MG-132 (CAS 1211877-36-9) - chemical structure image
Molecular structure of (R)-MG-132, CAS Number: 1211877-36-9
(R)-MG-132 (CAS 1211877-36-9) - chemical structure image
Molecular structure of (R)-MG-132, CAS Number: 1211877-36-9
Molecular structure of (R)-MG-132, CAS Number: 1211877-36-9

(R)-MG-132 (CAS 1211877-36-9)

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Alternate Names:
(R)-MG-132 is also known as Z-LLL-CHO.
Application:
(R)-MG-132 is a potent, cell-permeable, reversible and selective inhibitor, key in proteasome research.
CAS Number:
1211877-36-9
Purity:
≥98%
Molecular Weight:
475.62
Molecular Formula:
C26H41N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Description
Technical Information
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SDS & Certificate of Analysis

(R)-MG-132 is a research chemical utilized for its role as a proteasome inhibitor, which has significant implications in the study of protein degradation and turnover within cells. By inhibiting the proteasome, (R)-MG-132 allows scientists to understand the ubiquitin-proteasome pathway, a cellular system responsible for degrading misfolded or damaged proteins. This compound is useful in research related to cell cycle regulation and apoptosis, as the accumulation of proteins can trigger these processes. Additionally, (R)-MG-132 is employed to investigate the mechanisms of neurodegenerative conditions, where protein aggregation is a hallmark. The use of (R)-MG-132 in cellular models helps in delineating the pathways that contribute to the pathology of these conditions.


(R)-MG-132 (CAS 1211877-36-9) References

  1. Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells.  |  Zhang, XM., et al. 1999. Biochem J. 340 (Pt 1): 127-33. PMID: 10229667
  2. Bcl-2 antibodies induce hemoglobin release by red blood cells loaded with in vitro translated Bcl-2 and its cleaved fragment.  |  Chen, C., et al. 2000. Biochem Biophys Res Commun. 270: 816-20. PMID: 10772908
  3. Human THP-1 monocytic leukemic cells induced to undergo monocytic differentiation by bryostatin 1 are refractory to proteasome inhibitor-induced apoptosis.  |  Chen, C., et al. 2000. Cancer Res. 60: 4377-85. PMID: 10969781
  4. Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin.  |  Arlt, A., et al. 2001. Oncogene. 20: 859-68. PMID: 11314019
  5. Activation of the MEK/MAPK pathway is involved in bryostatin1-induced monocytic differenciation and up-regulation of X-linked inhibitor of apoptosis protein.  |  Lin, H., et al. 2002. Exp Cell Res. 272: 192-8. PMID: 11777344
  6. Transforming growth factor-beta inhibition of proteasomal activity: a potential mechanism of growth arrest.  |  Tadlock, L., et al. 2003. Am J Physiol Cell Physiol. 285: C277-85. PMID: 12646415
  7. Proteasome inhibition: a new anti-inflammatory strategy.  |  Elliott, PJ., et al. 2003. J Mol Med (Berl). 81: 235-45. PMID: 12700891
  8. [Enhanced apoptosis-inducing effect of etoposide on leukemic cell lines M-07e and TF-1 by the proteasome inhibitor Z-LLL-CHO].  |  Lan, Y., et al. 2003. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 11: 485-9. PMID: 14575542
  9. Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity.  |  Lin, G., et al. 2006. Mol Microbiol. 59: 1405-16. PMID: 16468985
  10. Synthesis, radiosynthesis, and biological evaluation of new proteasome inhibitors in a tumor targeting approach.  |  Vivier, M., et al. 2008. J Med Chem. 51: 1043-7. PMID: 18237109
  11. Effects of inhibition of ubiquitin-proteasome pathway on human primary leukemic cells.  |  Lan, Y., et al. 2002. Sci China C Life Sci. 45: 647-55. PMID: 18762897
  12. Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1.  |  Dębowski, D., et al. 2014. PLoS One. 9: e89465. PMID: 24586798
  13. Proteasome inhibitors: valuable new tools for cell biologists.  |  Lee, DH. and Goldberg, AL. 1998. Trends Cell Biol. 8: 397-403. PMID: 9789328

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(R)-MG-132, 1 mg

sc-351846
1 mg
$63.00

(R)-MG-132, 5 mg

sc-351846A
5 mg
$196.00

(R)-MG-132, 25 mg

sc-351846B
25 mg
$843.00

What is the chemical stability at -20°C of the MG132 once dissolved in ethanol and DMSO?

Asked by: anapaula
It is recommended that that stock solutions of sc-351846, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.
Answered by: Technical Support
Date published: 2019-09-11

What is the shipping temperature for this product?

Asked by: hawkeye11
This chemical, (R)-MG-132 (CAS 1211877-36-9), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-27
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Rated 5 out of 5 by from We used this in human cell lines in cellWe used this in human cell lines in cell culture and works well.
Date published: 2015-10-21
Rated 5 out of 5 by from Published paper in which we used it to elevatePublished paper in which we used it to elevate neuronal activity by treating primary mouse cortical neuron cultures.
Date published: 2015-08-12
Rated 5 out of 5 by from Use it routinely in labUse it routinely in lab, works fine.
Date published: 2015-05-19
Rated 5 out of 5 by from worked greatworked great, we have no complaints- 5 stars
Date published: 2015-04-07
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(R)-MG-132 is rated 5.0 out of 5 by 4.
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