Date published: 2025-9-25

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(R)-(+)-Glycidol (CAS 57044-25-4)

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Alternate Names:
(R)-(+)-Oxirane-2-methanol; (R)-3-hydroxy-1,2-epoxypropane; (R)-Oxiranemethanol
Application:
(R)-(+)-Glycidol is a chemical used toconstruct an epoxyvinyl iodide intermediate
CAS Number:
57044-25-4
Purity:
97%
Molecular Weight:
74.08
Molecular Formula:
C3H6O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(R)-(+)-Glycidol stands as a significant chiral epoxide employed extensively within the realm of organic synthesis. Its versatility and usefulness as a reagent make it invaluable for various synthetic transformations. In the domain of scientific research, (R)-(+)-Glycidol finds wide-ranging applications. Its role extends to being a foundational component in the synthesis of chiral compounds, including chiral alcohols, amines, and acids. Moreover, (R)-(+)-Glycidol exhibits catalytic properties, enabling its utilization in facilitating a myriad of reactions such as the Diels-Alder reaction and the epoxidation of alkenes. As an epoxide, (R)-(+)-Glycidol assumes a three-membered ring structure with an oxygen atom. This configuration imbues it with high reactivity, enabling it to engage in a diverse array of reactions encompassing addition, ring-opening, and cycloaddition reactions. Furthermore, (R)-Glycidol can serve as a catalyst for various reactions, including the Diels-Alder reaction and the epoxidation of alkenes.


(R)-(+)-Glycidol (CAS 57044-25-4) References

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  7. Chemisorptive enantioselectivity of chiral epoxides on tartaric-acid modified Pd(111): three-point bonding.  |  Mahapatra, M. and Tysoe, WT. 2015. Phys Chem Chem Phys. 17: 5450-8. PMID: 25615560
  8. Total Synthesis of (+)-Cryptocaryol A Using a Prins Cyclization/Reductive Cleavage Sequence.  |  Brun, E., et al. 2015. J Org Chem. 80: 8668-76. PMID: 26270107
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  11. Divergent Asymmetric Total Synthesis of All Four Pestalotin Diastereomers from (R)-Glycidol.  |  Moriyama, M., et al. 2020. Molecules. 25: PMID: 31963564
  12. Chiral Recognition of Homochiral Poly (amidoamine) Dendrimers Substituted with R- and S-Glycidol by Keratinocyte (HaCaT) and Squamous Carcinoma (SCC-15) Cells In Vitro.  |  Malinga-Drozd, M., et al. 2021. Polymers (Basel). 13: PMID: 33801610
  13. Synthesis of Biotinylated PAMAM G3 Dendrimers Substituted with R-Glycidol and Celecoxib/Simvastatin as Repurposed Drugs and Evaluation of Their Increased Additive Cytotoxicity for Cancer Cell Lines.  |  Wróbel, K., et al. 2022. Cancers (Basel). 14: PMID: 35158983

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(R)-(+)-Glycidol, 1 g

sc-253406
1 g
$35.00