Molecular structure of (R)-Flurbiprofen, CAS Number: 51543-40-9
(R)-Flurbiprofen (CAS 51543-40-9)
See product citations (2)
Alternate Names:
Tarenflurbil
Application:
(R)-Flurbiprofen is an inhibitor of γ-secretase and Cox
CAS Number:
51543-40-9
Purity:
>99%
Molecular Weight:
244.26
Molecular Formula:
C15H13FO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-Flurbiprofen may act to suppress prostate tumor cells by inducing p75NTR protein expression. (R)-Flurbiprofen inhibits the enzyme gamma-secretase thereby preventing the formation of the amyloid beta peptide (Abeta42) from amyloid beta precursor protein (APP). (R)-Flurbiprofen is an inhibitor of Cox.
(R)-Flurbiprofen (CAS 51543-40-9) References
- Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease. | Geerts, H. 2007. IDrugs. 10: 121-33. PMID: 17285465
- Retinoid X receptor-alpha mediates (R)-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. | You, X., et al. 2009. J Neurochem. 111: 142-9. PMID: 19659691
- R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction. | Jin, H., et al. 2010. Mol Pharm. 7: 156-68. PMID: 19916560
- R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. | Bishay, P., et al. 2010. PLoS One. 5: e10628. PMID: 20498712
- R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimer's disease as determined by MEMRI. | Smith, KD., et al. 2011. Magn Reson Med. 65: 1423-9. PMID: 21500269
- R-flurbiprofen, a novel nonsteroidal anti-inflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro. | Liu, JK., et al. 2012. J Neurooncol. 106: 561-9. PMID: 21938529
- R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. | Carreras, I., et al. 2013. Brain Res. 1541: 115-27. PMID: 24161403
- R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. | Schmitz, K., et al. 2014. EMBO Mol Med. 6: 1398-422. PMID: 25269445
- R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4. | Wobst, I., et al. 2016. Int J Mol Sci. 18: PMID: 28042832
- Combination of Paclitaxel and R-flurbiprofen loaded PLGA nanoparticles suppresses glioblastoma growth on systemic administration. | Caban-Toktas, S., et al. 2020. Int J Pharm. 578: 119076. PMID: 31988035
- Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models. | Buisseret, B., et al. 2021. FASEB J. 35: e21411. PMID: 33749884
- Comparison of percutaneous permeation profiles of flurbiprofen enantiomers. | Zhang, L., et al. 2022. Chirality. 34: 894-900. PMID: 35411968
- Human plasma concentrations of R, S, and racemic flurbiprofen given as a toothpaste. | Forland, SC., et al. 1996. J Clin Pharmacol. 36: 546-53. PMID: 8809639
Inhibitor of:
Cox, and Gamma-secretase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-Flurbiprofen, 10 mg | sc-205487 | 10 mg | $20.00 | |||
(R)-Flurbiprofen, 50 mg | sc-205487A | 50 mg | $61.00 |