(R)-Fluoxetine Hydrochloride (CAS 114247-09-5)
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(R)-Fluoxetine Hydrochloride is an isomer of Fluoxetine (sc-201125). Fluoxetine is a 5-hydroxytryptamine (serotonin, 5-HT) reuptake inhibitor. This compound is a racemic mixture and both R and S enantiomers are reported to inhibit 5-HT uptake in synaptosomal preparations of rat cerebral cortex. Fluoxetine is also noted to be a highly selective, sodium dependent, 5-HT transporter in studies of rat cerebrums. Additionally, Fluoxetine is also noted to increase extracellular levels of 5-HT in several areas of the rat brain as a result of reuptake inhibition. This increase in availability of 5-HT is reported to lead to a decrease in synthesis and turnover of 5-HT. Also available as (S)-Fluoxetine Hydrochloride (sc-208367).
(R)-Fluoxetine Hydrochloride (CAS 114247-09-5) References
- Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. | Wong, DT., et al. 1995. Life Sci. 57: 411-41. PMID: 7623609
- Fluoxetine selectively alters 5-hydroxytryptamine1A and gamma-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. | Beck, SG., et al. 1997. J Pharmacol Exp Ther. 281: 115-22. PMID: 9103487
- Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | Owens, MJ., et al. 1997. J Pharmacol Exp Ther. 283: 1305-22. PMID: 9400006
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-Fluoxetine Hydrochloride, 2.5 mg | sc-208240 | 2.5 mg | $317.00 |