Molecular structure of (R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)-amino)-9H-purin-2-yl)amino)butan-1-ol, CAS Number: 1056016-06-8
(R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)-amino)-9H-purin-2-yl)amino)butan-1-ol (CAS 1056016-06-8)
Alternate Names:
(R)-DRF053
Application:
(R)-DRF053 dihydrochloride is an ATP-competitive inhibitor of cyclin- dependent kinase and casein kinase 1
CAS Number:
1056016-06-8
Purity:
≥98%
Molecular Weight:
490.43
Molecular Formula:
C23H27N7O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-DRF053 dihydrochloride is a potent, ATP-competitive inhibitor of cdk (cyclin-dependent kinase) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for Cdc2 (cdk1)/cyclin B, cdk5/p25 and CK1 respectively). Shown to be selective over GSK-3 α/β (IC50= 4.1 μM).
(R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)-amino)-9H-purin-2-yl)amino)butan-1-ol (CAS 1056016-06-8) References
- Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. | Oumata, N., et al. 2008. J Med Chem. 51: 5229-42. PMID: 18698753
- Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases. | Perez, DI., et al. 2011. Med Res Rev. 31: 924-54. PMID: 20577972
- Protein kinase CK1α regulates erythrocyte survival. | Zelenak, C., et al. 2012. Cell Physiol Biochem. 29: 171-80. PMID: 22415086
- Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. | Bibian, M., et al. 2013. Bioorg Med Chem Lett. 23: 4374-80. PMID: 23787102
- Meta-Selective CAr-H Nitration of Arenes through a Ru3(CO)12-Catalyzed Ortho-Metalation Strategy. | Fan, Z., et al. 2016. J Am Chem Soc. 138: 8470-5. PMID: 27181121
- Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors. | Liu, KC., et al. 2018. Diabetes. 67: 58-70. PMID: 28986398
- AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation. | Yashima, H., et al. 2020. Int J Mol Sci. 21: PMID: 33291667
- Glucose-Dependent Insulinotropic Polypeptide Suppresses Foam Cell Formation of Macrophages through Inhibition of the Cyclin-Dependent Kinase 5-CD36 Pathway. | Terasaki, M., et al. 2021. Biomedicines. 9: PMID: 34356896
- Amyloid Cascade Hypothesis for the Treatment of Alzheimer's Disease: Progress and Challenges. | Wu, T., et al. 2022. Aging Dis. 13: 1745-1758. PMID: 36465173
- 'Dual Anta-Inhibitors' of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies. | Spinaci, A., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 37259317
Inhibitor of:
Casein Kinase, Cdc2, Cdk5, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)-amino)-9H-purin-2-yl)amino)butan-1-ol, 50 mg | sc-296248 | 50 mg | $800.00 | |||
(R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)-amino)-9H-purin-2-yl)amino)butan-1-ol, 100 mg | sc-296248A | 100 mg | $1400.00 |