Molecular structure of (R)-Desmethyl Citalopram Hydrochloride, CAS Number: 144010-85-5
(R)-Desmethyl Citalopram Hydrochloride (CAS 144010-85-5)
Alternate Names:
(1R)-1-(4-Fluorophenyl)-1,3-dihydro-1-[3-(methylamino)propyl]-5-isobenzofurancarbonitrile Hydrochloride; (R)-(−)-N-Demethylcitalopram Hydrochloride
Application:
(R)-Desmethyl Citalopram Hydrochloride is an enantiomer of Citalopram which acts as an inhibitor of 5-HT uptake
CAS Number:
144010-85-5
Molecular Weight:
346.83
Molecular Formula:
C19H20ClFN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
(R)-Desmethyl Citalopram Hydrochloride is a metabolite of Citalopram (sc-201123). Citalopram is a selective inhibitor of the 5-hydroxytryptamine transporter (serotonin) and therefore is a potent and selective SR (serotonin reuptake) inhibitor. Additional studies in indicate that Citalopram may be a weak, allosteric modulator of serotonin in a cross-species chimeric study. Studies also indicate that Citalopram is useful for studying gene expression patterns in circulating lymphocytes. In zebrafish, Citalopram is noted to reduce the frequency of NMDA-induced locomotor rhythm involved in swimming behavior.
(R)-Desmethyl Citalopram Hydrochloride (CAS 144010-85-5) References
- Plasma membrane monoamine transporters: structure, regulation and function. | Torres, GE., et al. 2003. Nat Rev Neurosci. 4: 13-25. PMID: 12511858
- The effect of citalopram on gene expression profile of Alzheimer lymphocytes. | Palotás, A., et al. 2004. Neurochem Res. 29: 1563-70. PMID: 15260135
- Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study. | Neubauer, HA., et al. 2006. Mol Pharmacol. 69: 1242-50. PMID: 16434615
- Serotonergic modulation of locomotion in zebrafish: endogenous release and synaptic mechanisms. | Gabriel, JP., et al. 2009. J Neurosci. 29: 10387-95. PMID: 19692613
Inhibitor of:
SR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-Desmethyl Citalopram Hydrochloride, 1 mg | sc-208237 | 1 mg | $337.00 |