Molecular structure of (R)-BEL, CAS Number: 478288-90-3
(R)-BEL (CAS 478288-90-3)
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Alternate Names:
(R)-Bromoenol lactone
Application:
(R)-BEL is an iPLA2γ inhibitor
CAS Number:
478288-90-3
Purity:
≥98%
Molecular Weight:
317.18
Molecular Formula:
C16H13BrO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-BEL is an irreversible, chiral, mechanism-based inhibitor of iPLA2gamma (IC50 ~ 0.6 muM). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2beta except at high doses (20-30 muM). (R)-BEL is a versatile compound that finds utility as a reagent in organic synthesis, a catalyst, and a fluorescent probe in biochemical research. In vitro studies have demonstrated the potential of (R)-BEL to impede the proliferation of specific cancer cell types.
(R)-BEL (CAS 478288-90-3) References
- Regulation and inhibition of phospholipase A2. | Balsinde, J., et al. 1999. Annu Rev Pharmacol Toxicol. 39: 175-89. PMID: 10331081
- Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. | Jenkins, CM., et al. 2002. J Biol Chem. 277: 32807-14. PMID: 12089145
- Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse. | Sharma, J., et al. 2010. Biochemistry. 49: 5473-81. PMID: 20521843
- Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. | Rastogi, P., et al. 2011. Urology. 77: 248.e1-7. PMID: 21094990
- The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. | Pattabiraman, PP., et al. 2012. Am J Physiol Cell Physiol. 302: C979-91. PMID: 22237407
- Absence of calcium-independent phospholipase A2 β impairs platelet-activating factor production and inflammatory cell recruitment in Trypanosoma cruzi-infected endothelial cells. | Sharma, J., et al. 2014. Physiol Rep. 2: e00196. PMID: 24744875
- Calcium-independent phospholipase A2γ enhances activation of the ATF6 transcription factor during endoplasmic reticulum stress. | Elimam, H., et al. 2015. J Biol Chem. 290: 3009-20. PMID: 25492867
- Cigarette smoke induces cell motility via platelet-activating factor accumulation in breast cancer cells: a potential mechanism for metastatic disease. | Kispert, S., et al. 2015. Physiol Rep. 3: PMID: 25802360
- Asymmetrical diacylglycerol dynamics on the cytosolic and lumenal sides of a single endomembrane in living cells. | Ueda, Y., et al. 2015. Sci Rep. 5: 12960. PMID: 26264517
- LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase (ATGL). | Chen, G., et al. 2016. Sci Rep. 6: 35531. PMID: 27759039
- Cigarette smoke-induced urothelial cell damage: potential role of platelet-activating factor. | Kispert, SE., et al. 2017. Physiol Rep. 5: PMID: 28270596
- Cytoprotective activity of mitochondrial uncoupling protein-2 in lung and spleen. | Jabůrek, M., et al. 2018. FEBS Open Bio. 8: 692-701. PMID: 29632821
- Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation. | Wagner, C., et al. 2020. Biochim Biophys Acta Mol Cell Biol Lipids. 1865: 158730. PMID: 32361002
Inhibitor of:
Enzyme, iPLA2, and PLA1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-BEL, 500 µg | sc-222233 | 500 µg | $31.00 | |||
(R)-BEL, 1 mg | sc-222233A | 1 mg | $78.00 |