Date published: 2026-5-14

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R-BAIBA (CAS 2140-95-6)

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Alternate Names:
D-3-Amino-isobutyric acid; D-BAIBA
CAS Number:
2140-95-6
Molecular Weight:
103.12
Molecular Formula:
C4H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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R-BAIBA is a compound that functions as a PPARα agonist, activating peroxisome proliferator-activated receptor alpha. This activation leads to the upregulation of genes involved in fatty acid oxidation and energy expenditure. R-BAIBA also plays a role in regulating lipid metabolism and glucose homeostasis by increasing the expression of genes involved in these processes. At the molecular level, R-BAIBA interacts with PPARα, leading to conformational changes that allow it to bind to specific DNA sequences and modulate gene expression. This R-BAIBA′s mechanism of action involves the activation of signaling pathways that regulate metabolic processes, making it useful for studying the molecular mechanisms underlying metabolic diseases and energy metabolism.


R-BAIBA (CAS 2140-95-6) References

  1. Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver.  |  Tamaki, N., et al. 1990. Eur J Biochem. 189: 39-45. PMID: 2158891
  2. Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism.  |  Tanianskii, DA., et al. 2019. Nutrients. 11: PMID: 30823446
  3. Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans.  |  Stautemas, J., et al. 2019. Front Physiol. 10: 1240. PMID: 31611815
  4. Metabolic Health-The Role of Adipo-Myokines.  |  Graf, C. and Ferrari, N. 2019. Int J Mol Sci. 20: PMID: 31817641
  5. Exercise and browning of white adipose tissue - a translational perspective.  |  Severinsen, MCK., et al. 2020. Curr Opin Pharmacol. 52: 18-24. PMID: 32480032
  6. Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism.  |  Barlow, JP., et al. 2020. Metabol Open. 7: 100053. PMID: 32924003
  7. Potential Roles of Exercise-Induced Plasma Metabolites Linking Exercise to Health Benefits.  |  Yang, YR. and Kwon, KS. 2020. Front Physiol. 11: 602748. PMID: 33343398
  8. The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue.  |  Atakan, MM., et al. 2021. Nutrients. 13: PMID: 33922998
  9. Metabolic Snapshot of Plasma Samples Reveals New Pathways Implicated in SARS-CoV-2 Pathogenesis.  |  Albóniga, OE., et al. 2022. J Proteome Res. 21: 623-634. PMID: 35133846
  10. Influence of Nutritional Status and Physical Exercise on Immune Response in Metabolic Syndrome.  |  Lombardo, M., et al. 2022. Nutrients. 14: PMID: 35631195
  11. Elevated circulating level of β-aminoisobutyric acid (BAIBA) in heart failure patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitors.  |  Katano, S., et al. 2022. Cardiovasc Diabetol. 21: 285. PMID: 36539818
  12. High-performance liquid chromatographic determination of beta-alanine, beta-aminoisobutyric acid and gamma-aminobutyric acid in tissue extracts and urine of normal and (aminooxy)acetate-treated rats.  |  Abe, T., et al. 1998. J Chromatogr B Biomed Sci Appl. 712: 43-9. PMID: 9698227
  13. Dietary GABA and its combination with vigabatrin mimic calorie restriction and induce antiobesity-like effects in lean mice  |  Sato, K., Komaru, T., Arima, T., Jardson, C., Yanaka, N., & Kumrungsee, T. 2021. Journal of Functional Foods. 78: 104367.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

R-BAIBA, 100 mg

sc-505918
100 mg
$357.00