(R)-(-)-Apomorphine hydrochloride is a prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). (R)-(-)-Apomorphine hydrochloride, produces biphasic effects on locomotor activity, displays antiparkinsonian, and neuroprotective actions when systemically administered in vivo.
1. Liu, X., et al. 1996. Pharmacol. Biochem. Behav. 53: 335-340. PMID: 8808141 2. Grunblatt, E., et al. 1999. Mov. Disord. 14: 612-618. PMID: 10435498 3. Millan, M.J., et al. 2002. J. Pharmacol. Exp. Ther. 303: 791-804. PMID: 12388666
Soluble in water (50 mM), and DMSO (100 mM). and mixes with alcohol (1:50).
Rated 5 out of
YanYan, T. et al. (PubMed 25744977) reported that daily injection but not continous infusion of (R)-(-)-Apomorphine inhibits form-deprivation myopia in mice. -SCBT Publication Review
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