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(R)-(−)-Apomorphine hydrochloride (CAS 314-19-2) - chemical structure image
Molecular structure of (R)-(−)-Apomorphine hydrochloride, CAS Number: 314-19-2
(R)-(−)-Apomorphine hydrochloride (CAS 314-19-2) - chemical structure image
Molecular structure of (R)-(−)-Apomorphine hydrochloride, CAS Number: 314-19-2
Molecular structure of (R)-(−)-Apomorphine hydrochloride, CAS Number: 314-19-2

(R)-(−)-Apomorphine hydrochloride (CAS 314-19-2)

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Application:
(R)-(−)-Apomorphine hydrochloride is a prototypical dopamine agonist
CAS Number:
314-19-2
Purity:
>95%
Molecular Weight:
303.79
Molecular Formula:
C17H17NO2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Description
Technical Information
Safety Information
SDS & Certificate of Analysis

(R)-(−)-Apomorphine hydrochloride is a compound consisting of apomorphine and hydrochloric acid. It functions as a prototypical dopamine agonist. Being a dopamine agonist, (R)-(−)-Apomorphine hydrochloride binds to dopamine receptors and activates them. In vitro experiments have focused on evaluating the influence of (R)-(−)-Apomorphine hydrochloride on cell signaling pathways, gene expression, and cell morphology.


(R)-(−)-Apomorphine hydrochloride (CAS 314-19-2) References

  1. Apomorphine up-regulates NGF and GDNF synthesis in cultured mouse astrocytes.  |  Ohta, M., et al. 2000. Biochem Biophys Res Commun. 272: 18-22. PMID: 10872797
  2. Effects of conantokins on L-3,4-dihydroxyphenylalanine-induced behavior and immediate early gene expression.  |  Adams, AC., et al. 2000. Eur J Pharmacol. 404: 303-13. PMID: 10996596
  3. Stability of apomorphine hydrochloride in aqueous sodium bisulphite solutions.  |  Ng Ying Kin, NM., et al. 2001. Prog Neuropsychopharmacol Biol Psychiatry. 25: 1461-8. PMID: 11513359
  4. Transdermal permeation of apomorphine through hairless mouse skin from microemulsions.  |  Peira, E., et al. 2001. Int J Pharm. 226: 47-51. PMID: 11532569
  5. Pretreatment with a water-based surfactant formulation affects transdermal iontophoretic delivery of R-apomorphine in vitro.  |  Li, GL., et al. 2003. Pharm Res. 20: 653-9. PMID: 12739775
  6. The role of dopamine receptors in ventrolateral orbital cortex-evoked antinociception in a rat formalin test model.  |  Dang, YH., et al. 2011. Eur J Pharmacol. 657: 97-103. PMID: 21316357
  7. Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.  |  Thomas, AG., et al. 2013. Biochem Biophys Res Commun. 438: 243-8. PMID: 23850693
  8. Intracerebral injection of R-(-)-Apomorphine into the nucleus accumbens decreased carbachol-induced 22-kHz ultrasonic vocalizations in rats.  |  Silkstone, M. and Brudzynski, SM. 2019. Behav Brain Res. 364: 264-273. PMID: 30690109
  9. The antagonistic relationship between aversive and appetitive emotional states in rats as studied by pharmacologically-induced ultrasonic vocalization from the nucleus accumbens and lateral septum.  |  Silkstone, M. and Brudzynski, SM. 2019. Pharmacol Biochem Behav. 181: 77-85. PMID: 31034853
  10. Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model.  |  Park, HW., et al. 2020. Sci Rep. 10: 9572. PMID: 32533070
  11. Vascular effects of apomorphine and related compounds in the perfused rat kidney.  |  Schmidt, M., et al. 1984. Eur J Pharmacol. 97: 75-85. PMID: 6141949
  12. Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats.  |  Jensen, TS. and Yaksh, TL. 1984. Brain Res. 296: 285-93. PMID: 6322926
  13. The role of spinal pathways in dopamine mediated alteration in the tail-flick reflex in rats.  |  Jensen, TS., et al. 1984. Neuropharmacology. 23: 149-53. PMID: 6546973
  14. Distribution of apomorphine enantiomers in plasma, brain tissue and striatal extracellular fluid.  |  Sam, E., et al. 1997. Eur J Pharmacol. 329: 9-15. PMID: 9218678
  15. Naloxone does not alter amphetamine-induced rotational behavior or striatal dopamine levels of nigrally-lesioned rats.  |  Kimmel, HL., et al. 1998. Brain Res. 789: 171-4. PMID: 9602114

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(R)-(−)-Apomorphine hydrochloride, 5 mg

sc-203675A
5 mg
$84.00

(R)-(−)-Apomorphine hydrochloride, 50 mg

sc-203675
50 mg
$161.00

(R)-(−)-Apomorphine hydrochloride, 500 mg

sc-203675B
500 mg
$421.00

do I need to prepare the apomorphine fresh when I inject it into PD mouse model?

Asked by: hehe
Thank you for your question. We do not support our biochemicals for use in vivo. They are recommended for in vitro research use only.
Answered by: Technical Service
Date published: 2016-11-01
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Rated 5 out of 5 by from YanYan, T. et al. (PubMed 25744977) reported that daily injection but not continous infusion of (R)-(-)-Apomorphine inhibits form-deprivation myopia in mice. -SCBT Publication Review
Date published: 2015-04-14
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(R)-(−)-Apomorphine hydrochloride is rated 5.0 out of 5 by 1.
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