Molecular structure of R-96544 hydrochloride, CAS Number: 167144-80-1
R-96544 hydrochloride (CAS 167144-80-1)
Alternate Names:
(2R,4R)-5-[2-[2-[2-(3-Methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-3-pyrrolidinol hydrochloride
Application:
R-96544 hydrochloride is a potent and selective SR-2 antagonist
CAS Number:
167144-80-1
Molecular Weight:
391.94
Molecular Formula:
C22H29NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
R-96544 hydrochloride is a compound that functions as a potent and selective inhibitor of a specific enzyme. It acts by binding to the active site of the enzyme, preventing its normal function and disrupting the biochemical pathway in which it is involved. This disruption leads to a cascade of downstream effects, ultimately influencing cellular processes related to the enzyme′s function. The compound′s mechanism of action involves interfering with the enzyme′s ability to catalyze specific chemical reactions, thereby modulating the activity of key signaling pathways within the cell. R-96544 hydrochloride plays a role in experimental applications by providing a means to selectively manipulate the activity of the target enzyme, allowing for the study of its function and the downstream effects of its inhibition.
R-96544 hydrochloride (CAS 167144-80-1) References
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- Effects of R-102444, an orally active 5-HT2A receptor antagonist, in rat models of peripheral vascular disease. | Ogawa, T., et al. 2004. Vascul Pharmacol. 41: 7-13. PMID: 15135326
- Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis. | Ogawa, T., et al. 2005. Eur J Pharmacol. 521: 156-63. PMID: 16183055
- Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. | Shioda, K., et al. 2008. Neurotoxicology. 29: 1030-6. PMID: 18722468
- Involvement of local serotonin-2A but not serotonin-1B receptors in the reinforcing effects of ethanol within the posterior ventral tegmental area of female Wistar rats. | Ding, ZM., et al. 2009. Psychopharmacology (Berl). 204: 381-90. PMID: 19165471
- Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine. | Katsidoni, V., et al. 2011. Psychopharmacology (Berl). 213: 337-54. PMID: 20577718
- Central 5-HT(2A) receptors modulate the vagal bradycardia in response to activation of the von Bezold-Jarisch reflex in anesthetized rats. | Futuro Neto, HA., et al. 2011. Braz J Med Biol Res. 44: 224-8. PMID: 21344136
- Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome. | Xu, ZH., et al. 2012. PLoS One. 7: e48741. PMID: 23119095
- Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways. | Biagioni, AF., et al. 2013. Neuropharmacology. 67: 379-94. PMID: 23201351
- The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT₂A and 5-HT₂C serotonergic receptors in post-ictal antinociception. | de Freitas, RL., et al. 2014. Synapse. 68: 16-30. PMID: 23913301
- The μ1-opioid receptor and 5-HT2A- and 5HT2C-serotonergic receptors of the locus coeruleus are critical in elaborating hypoalgesia induced by tonic and tonic-clonic seizures. | de Freitas, RL., et al. 2016. Neuroscience. 336: 133-145. PMID: 27600945
- 5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus. | da Silva Soares, R., et al. 2019. Behav Brain Res. 357-358: 71-81. PMID: 28736332
- Dorsal raphe nucleus 5-Hydroxytryptamine 2A receptors are critical for the organisation of panic attack-like defensive behaviour and unconditioned fear-induced antinociception elicited by the chemical stimulation of superior colliculus neurons. | da Silva Soares, R., et al. 2019. Eur Neuropsychopharmacol. 29: 858-870. PMID: 31227263
- Stimulation of 5-HT receptors in anterodorsal BNST guides fear to predictable and unpredictable threat. | Hessel, M., et al. 2020. Eur Neuropsychopharmacol. 39: 56-69. PMID: 32873441
Inhibitor of:
SR-2A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R-96544 hydrochloride, 10 mg | sc-204223 | 10 mg | $165.00 | |||
| US: Only available in the US | ||||||
R-96544 hydrochloride, 50 mg | sc-204223A | 50 mg | $676.00 | |||
| US: Only available in the US | ||||||