Molecular structure of (R)-(+)-8-Hydroxy-DPAT hydrobromide, CAS Number: 78095-19-9
(R)-(+)-8-Hydroxy-DPAT hydrobromide (CAS 78095-19-9)
Alternate Names:
(R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
Application:
(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full SR-1A agonist
CAS Number:
78095-19-9
Purity:
≥98%
Molecular Weight:
328.29
Molecular Formula:
C16H25NO•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-(+)-8-Hydroxy-DPAT is a full 5-HT1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.
(R)-(+)-8-Hydroxy-DPAT hydrobromide (CAS 78095-19-9) References
- 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors. | Cloëz-Tayarani, I., et al. 2004. Life Sci. 76: 429-43. PMID: 15530505
- In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\ increased motor disability. | Iravani, MM., et al. 2006. J Pharmacol Exp Ther. 319: 1225-34. PMID: 16959959
- 5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. | Mizutani, H., et al. 2006. Eur J Neurosci. 24: 1946-54. PMID: 17067296
- Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram. | Rossi, DV., et al. 2008. Eur J Pharmacol. 583: 103-7. PMID: 18289523
- Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro. | Yoshida, H., et al. 2011. Neurosci Res. 71: 311-4. PMID: 21802453
- The reversal of cognitive, but not negative or positive symptoms of schizophrenia, by the mGlu₂/₃ receptor agonist, LY379268, is 5-HT₁A dependent. | Wierońska, JM., et al. 2013. Behav Brain Res. 256: 298-304. PMID: 23948211
- The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. | Wierońska, JM., et al. 2015. Psychopharmacology (Berl). 232: 259-73. PMID: 25012236
- Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin. | Bonchak, JG., et al. 2014. Arch Biochem Biophys. 563: 71-8. PMID: 25132642
- Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-2022. | Woźniak, M., et al. 2017. Neuropharmacology. 115: 149-165. PMID: 27465045
- Treatment with Shuyu capsule increases 5-HT1AR level and activation of cAMP-PKA-CREB pathway in hippocampal neurons treated with serum from a rat model of depression. | Wang, XL., et al. 2018. Mol Med Rep. 17: 3575-3582. PMID: 29286104
- Neurochemical changes underlying schizophrenia-related behavior in a modified forced swim test in mice. | Woźniak, M., et al. 2018. Pharmacol Biochem Behav. 172: 50-58. PMID: 29913190
- 5-HT1A Receptor Function Makes Wound Healing a Happier Process. | Sadiq, A., et al. 2018. Front Pharmacol. 9: 1406. PMID: 30618734
- Effects of repeated treatment with the 5-HT1A and 5-HT1B agonists (R)-( +)-8-hydroxy-DPAT and CP-94253 on the locomotor activity and axillary temperatures of preweanling rats: evidence of tolerance and behavioral sensitization. | McDougall, SA., et al. 2022. Psychopharmacology (Berl). 239: 413-427. PMID: 34816290
Activator of:
SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-(+)-8-Hydroxy-DPAT hydrobromide, 5 mg | sc-253404 | 5 mg | $131.00 | |||
(R)-(+)-8-Hydroxy-DPAT hydrobromide, 25 mg | sc-253404A | 25 mg | $480.00 |