R-(-)-O-Desmethyl Venlafaxine CAS: 142761-11-3
MF: C16H25NO2
MW: 263.38
A venlafaxine metabolite.

R-(-)-O-Desmethyl Venlafaxine (CAS 142761-11-3)

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Application: R-(−)-O-Desmethyl Venlafaxine is a venlafaxine metabolite
CAS Number: 142761-11-3
Molecular Weight: 263.38
Molecular Formula: C16H25NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

R-(-)-O-Desmethyl Venlafaxine is a metabolite of R-Venlafaxine (sc-208209), a selective serotonin noradrenaline reuptake inhibitor. This bicyclic molecule facilitates neurotransmission by preventing presynaptic reuptake, resulting in a higher concentration of neurotransmitters located within the synapse. It is known that the neurotransmitters most effected by this inhibitor are norepinephrine and serotonin, which weakly suppress dopamine at high concentrations. Furthermore, studies show that R-(-)-O-Desmethyl Venlafaxine can be seperated from Venlafaxine using LC-MS/MS in rat plasma.


References

1. Holdcroft, C. 1994. Nurse Pract. 19: 21. PMID: 7816367
2. Holliday, S.M. and Benfield, P. 1995. Drugs. 49: 280-294. PMID: 7729333
3. Shah, G.R., et al. 2009. Anal Sci. 25: 1207-1210. PMID: 19822964

Physical State :
Solid
Solubility :
Soluble in ethanol, and methanol.
Storage :
Store at -20° C
Melting Point :
208-213° C
Boiling Point :
403.79° C at 760 mmHg (Predicted)
Density :
1.12 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
12018336
MDL Number :
MFCD04039503
SMILES :
CN(C)C[[email protected]@H](C1=CC=C(O)C=C1)C1(O)CCCCC1

Download SDS (MSDS)

Certificate of Analysis

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