R-(-)-O-Desmethyl Venlafaxine (CAS 142761-11-3)

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Application: R-(−)-O-Desmethyl Venlafaxine is a venlafaxine metabolite

CAS Number: 142761-11-3

Molecular Weight: 263.38

Molecular Formula: C₁₆H₂₅NO₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

R-(-)-O-Desmethyl Venlafaxine: sc-208198...

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R-(-)-O-Desmethyl Venlafaxine is a metabolite of R-Venlafaxine (sc-208209), a selective serotonin noradrenaline reuptake inhibitor. This bicyclic molecule facilitates neurotransmission by preventing presynaptic reuptake, resulting in a higher concentration of neurotransmitters located within the synapse. It is known that the neurotransmitters most effected by this inhibitor are norepinephrine and serotonin, which weakly suppress dopamine at high concentrations. Furthermore, studies show that R-(-)-O-Desmethyl Venlafaxine can be seperated from Venlafaxine using LC-MS/MS in rat plasma.

References

1. Holdcroft, C. 1994. Nurse Pract. 19: 21. PMID: 7816367
2. Holliday, S.M. and Benfield, P. 1995. Drugs. 49: 280-294. PMID: 7729333
3. Shah, G.R., et al. 2009. Anal Sci. 25: 1207-1210. PMID: 19822964

Physical State :

Solid

Solubility :

Soluble in ethanol, and methanol.

Storage :

Store at -20° C

Melting Point :

208-213° C

Boiling Point :

403.79° C at 760 mmHg (Predicted)

Density :

1.12 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.57 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

12018336

MDL Number :

MFCD04039503

SMILES :

CN(C)C[[email protected]@H](C1=CC=C(O)C=C1)C1(O)CCCCC1

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Certificate of Analysis

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