Date published: 2026-4-26

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R-(+)-DIOA (CAS 81166-47-4)

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Alternate Names:
R-(+)-Butylindazone; (Dihydroindenyl)oxy alkanoic acid
Application:
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system
CAS Number:
81166-47-4
Purity:
≥98%
Molecular Weight:
399.31
Molecular Formula:
C20H24Cl2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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R-(+)-DIOA is a research chemical primarily used in biochemistry to study ion transport mechanisms across cell membranes. This compound is known as an inhibitor of the outwardly rectifying chloride channel (ORCC), which plays a significant role in chloride ion transport in various cell types. The specificity of R-(+)-DIOA for these channels enables researchers to investigate the physiological and pathological roles of ORCCs, such as their involvement in cell volume regulation and their potential contribution to cystic fibrosis. Additionally, R-(+)-DIOA is used in electrophysiological experiments to understand the kinetic properties of chloride channels and to characterize the effects of channel modulation on cellular functions. The enantiomerically pure form, indicated by the R-(+)- prefix, allows for the exploration of stereoselectivity in the interaction between the compound and the chloride channels. R-(+)-DIOA is also valuable in studying the structure-activity relationships of ORCC inhibitors, contributing to the development of more selective and potent compounds for research applications.


R-(+)-DIOA (CAS 81166-47-4) References

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  2. Functional properties of the apical Na+-K+-2Cl- cotransporter isoforms.  |  Plata, C., et al. 2002. J Biol Chem. 277: 11004-12. PMID: 11790783
  3. Relative contribution of chloride channels and transporters to regulatory volume decrease in human glioma cells.  |  Ernest, NJ., et al. 2005. Am J Physiol Cell Physiol. 288: C1451-60. PMID: 15659714
  4. Volume regulation following hyposmotic shock in isolated turbot (Scophthalmus maximus) hepatocytes.  |  Ollivier, H., et al. 2006. J Comp Physiol B. 176: 393-403. PMID: 16395590
  5. Expression of mouse osteoclast K-Cl Co-transporter-1 and its role during bone resorption.  |  Kajiya, H., et al. 2006. J Bone Miner Res. 21: 984-92. PMID: 16813519
  6. K+-Cl- Cotransporter-3a Up-regulates Na+,K+-ATPase in Lipid Rafts of Gastric Luminal Parietal Cells.  |  Fujii, T., et al. 2008. J Biol Chem. 283: 6869-77. PMID: 18178552
  7. Arachidonic Acid Activates K-Cl-cotransport in HepG2 Human Hepatoblastoma Cells.  |  Lee, YS. 2009. Korean J Physiol Pharmacol. 13: 401-8. PMID: 19915704
  8. Blockade of chloride ion transport enhances the cytocidal effect of hypotonic solution in gastric cancer cells.  |  Iitaka, D., et al. 2012. J Surg Res. 176: 524-34. PMID: 22261593
  9. Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.  |  Okada-Ogawa, A., et al. 2015. Exp Neurol. 267: 42-52. PMID: 25736265
  10. Inhibition of K+ efflux and dehydration of sickle cells by [(dihydroindenyl)oxy]alkanoic acid: an inhibitor of the K+ Cl- cotransport system.  |  Vitoux, D., et al. 1989. Proc Natl Acad Sci U S A. 86: 4273-6. PMID: 2726772
  11. The significance of the relative effects of loop diuretics and anti-brain edema agents on the Na+,K+,Cl- cotransport system and the Cl-/NaCO3- anion exchanger.  |  Garay, RP., et al. 1986. Naunyn Schmiedebergs Arch Pharmacol. 334: 202-9. PMID: 3097557
  12. Regulatory volume decrease in lamprey erythrocytes: mechanisms of K+ and Cl- loss.  |  Virkki, LV. and Nikinmaa, M. 1995. Am J Physiol. 268: R590-7. PMID: 7900900

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

R-(+)-DIOA, 5 mg

sc-203230
5 mg
$223.00

R-(+)-DIOA, 25 mg

sc-203230A
25 mg
$859.00