Molecular structure of R-(+)-Baclofen (free base), CAS Number: 69308-37-8
R-(+)-Baclofen (free base) (CAS 69308-37-8)
Application:
R-(+)-Baclofen (free base) is a selective GABAB receptor agonist
CAS Number:
69308-37-8
Molecular Weight:
213.66
Molecular Formula:
C10H12ClNO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
R-(+)-Baclofen (free base) is a selective GABAB receptor agonist. GABAB receptors are metabotropic receptors which produce slow inhibitory signals. By manipulating GABAB receptor activity using Baclofen, a variety of functions are studied including synaptic transmissions and antinociception events.
R-(+)-Baclofen (free base) (CAS 69308-37-8) References
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- Intra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice. | Kasten, CR. and Boehm, SL. 2014. Behav Brain Res. 272: 238-47. PMID: 25026094
- R(+)-Baclofen, but Not S(-)-Baclofen, Alters Alcohol Self-Administration in Alcohol-Preferring Rats. | Lorrai, I., et al. 2016. Front Psychiatry. 7: 68. PMID: 27148096
- Developing a model of limited-access nicotine consumption in C57Bl/6J mice. | Kasten, CR., et al. 2016. Pharmacol Biochem Behav. 148: 28-37. PMID: 27242276
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- Non-genetic factors that influence methamphetamine intake in a genetic model of differential methamphetamine consumption. | Stafford, AM., et al. 2020. Psychopharmacology (Berl). 237: 3315-3336. PMID: 32833064
- 3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity. | Witczuk, B., et al. 1980. Pol J Pharmacol Pharm. 32: 187-96. PMID: 7454623
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Inhibitor of:
AChRα7, and GABAB R1.Activator of:
G α o, and GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R-(+)-Baclofen (free base), 10 mg | sc-203228 | 10 mg | $50.00 | |||
R-(+)-Baclofen (free base), 50 mg | sc-203228A | 50 mg | $195.00 |