QX 314 chloride CAS: 5369-03-9
MF: C16H27N2O•Cl
MW: 298.85
A voltage-activated Na+ channel blocker.

QX 314 chloride (CAS 5369-03-9)

QX 314 chloride | CAS 5369-03-9 is rated 5.0 out of 5 by 1.
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Alternate Names: Lidocaine N-ethyl chloride; N-(2,6-dimethylphenylcarbamoylmethyl)triethylammonium chloride
Application: QX 314 chloride is a voltage-activated Na+ channel blocker
CAS Number: 5369-03-9
Purity: ≥99%
Molecular Weight: 298.85
Molecular Formula: C16H27N2O•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker.


References

1. Stichartz, G.R., et al. 1973. J. Gen. Physiol. 63: 37-57.
2. Alreja, M. and Aghajanian, G.K. 1994. Brain Res. 639: 320-324.
3. Perkins, K.L. and Wong, R.K. 1995. J. Neurophysiol. 72: 911-915.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (50 mM).
Storage :
Desiccate at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
BT0430000
PubChem CID :
MDL Number :
MFCD01669894
SMILES :
CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Cl-]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Zhao Zhao, Y. et al. (PubMed 24932639) used QX 314 chloride, a voltage-activated Na+ channel blocker, to test whether it could produce long-lasting intravenous regional anesthesia in a rat model. QX 314 proved successful and toxic analysis confirmed that low but relevant doses of QX 314 did not result in any measurable toxicity. -SCBT Publication Review
Date published: 2015-06-16
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