Molecular structure of QX 314 chloride, CAS Number: 5369-03-9
QX 314 chloride (CAS 5369-03-9)
Alternate Names:
Lidocaine N-ethyl chloride; N-(2,6-dimethylphenylcarbamoylmethyl)triethylammonium chloride
Application:
QX 314 chloride is a voltage-activated Na+ channel blocker
CAS Number:
5369-03-9
Purity:
≥99%
Molecular Weight:
298.85
Molecular Formula:
C16H27N2O•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker. In experimental applications, QX-314 chloride′s ability to selectively inhibit certain types of nerve fibers while leaving others unaffected provides useful for scientists investigating the specific roles of different nerve fibers in pain, sensation, and motor function. This specificity allows for detailed studies on the pathways involved in pain perception and the transmission of nerve signals. Additionally, the compound has been used in basic research to better understand the fundamental principles of neuronal function and the biophysical properties of sodium channels.
QX 314 chloride (CAS 5369-03-9) References
- gamma-Aminobutyrate, alpha-carboxy-2-nitrobenzyl ester selectively blocks inhibitory synaptic transmission in rat dentate gyrus. | Molnár, P. and Nadler, JV. 2000. Eur J Pharmacol. 391: 255-62. PMID: 10729366
- Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy. | Molnár, P. and Nadler, JV. 2001. J Neurophysiol. 85: 1932-40. PMID: 11353010
- Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. | Toyoda, H., et al. 2005. Eur J Neurosci. 22: 485-94. PMID: 16045501
- Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. | Zhao, MG., et al. 2005. J Neurosci. 25: 7385-92. PMID: 16093389
- Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat. | Vikman, KS., et al. 2008. J Physiol. 586: 515-27. PMID: 18033811
- Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. | Wu, LJ., et al. 2008. Eur J Neurosci. 27: 1923-32. PMID: 18412613
- The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. | Rivera-Acevedo, RE., et al. 2011. Anesthesiology. 114: 1425-34. PMID: 21502857
- The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina. | Murphy-Baum, BL. and Taylor, WR. 2015. J Neurosci. 35: 13336-50. PMID: 26424882
- Distinct Synaptic Strengthening of the Striatal Direct and Indirect Pathways Drives Alcohol Consumption. | Cheng, Y., et al. 2017. Biol Psychiatry. 81: 918-929. PMID: 27470168
- Abstinence from Cocaine-Induced Conditioned Place Preference Produces Discrete Changes in Glutamatergic Synapses onto Deep Layer 5/6 Neurons from Prelimbic and Infralimbic Cortices. | Pena-Bravo, JI., et al. 2017. eNeuro. 4: PMID: 29242822
- Nano-engineered microcapsules boost the treatment of persistent pain. | Kopach, O., et al. 2018. Drug Deliv. 25: 435-447. PMID: 29383961
- The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors. | Lopes, JP., et al. 2019. Biochem Pharmacol. 166: 313-321. PMID: 31199895
- Local anesthetic block of batrachotoxin-resistant muscle Na+ channels. | Wang, GK., et al. 1998. Mol Pharmacol. 54: 389-96. PMID: 9687581
Inhibitor of:
Na+ CP type IIIα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
QX 314 chloride, 50 mg | sc-203674 | 50 mg | $196.00 | |||
QX 314 chloride, 100 mg | sc-203674A | 100 mg | $259.00 | |||
QX 314 chloride, 500 mg | sc-203674B | 500 mg | $587.00 | |||
QX 314 chloride, 1 g | sc-203674C | 1 g | $863.00 |