Molecular structure of QX-314, CAS Number: 21306-56-9
QX-314 (CAS 21306-56-9)
See product citations (14)
Alternate Names:
Lidocaine N-ethyl bromide
Application:
QX-314 is a sodium channel protein inhibitor
CAS Number:
21306-56-9
Purity:
≥98%
Molecular Weight:
343.30
Molecular Formula:
C16H27N2O•Br
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
QX-314 is a quarternary lidocaine (sc-204056) derivative which acts as a local anesthetic and a strong sodium channel protein inhibitor of intracellular voltage-sensitive sodium ion conductance. QX-314 effectively blocks cardiac Na+ channels when applied from either side of the membrane, but blocks neuronal Na+channels only from the intracellular side. Externally applied QX-314 was shown to inhibit high frequency activity in sensory nerves. The Na+ dependent action potential is completely blocked approximately five minutes after impalement with approximately 50 mM QX-314 containing microelectrode, whereas the low-threshold Ca2+ spike is still generated.
QX-314 (CAS 21306-56-9) References
- Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. | Brenneis, C., et al. 2014. Br J Pharmacol. 171: 438-51. PMID: 24117225
- External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1. | Hofmann, ME., et al. 2014. J Neurophysiol. 112: 2697-706. PMID: 25185814
- Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity. | Stueber, T., et al. 2016. Anesthesiology. 124: 1153-65. PMID: 26859646
- Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice. | Fuseya, S., et al. 2016. Anesthesiology. 125: 204-18. PMID: 27176211
- The quaternary lidocaine derivative QX-314 in combination with bupivacaine for long-lasting nerve block: Efficacy, toxicity, and the optimal formulation in rats. | Yin, Q., et al. 2017. PLoS One. 12: e0174421. PMID: 28334014
- QX-OH, a QX-314 derivative agent, produces long-acting local anesthesia in rats. | Zhang, Y., et al. 2017. Eur J Pharm Sci. 105: 212-218. PMID: 28529036
- Addition of dexmedetomidine to QX-314 enhances the onset and duration of sciatic nerve block in rats. | Zhao, W., et al. 2018. Can J Physiol Pharmacol. 96: 388-394. PMID: 28886259
- Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats. | Yoon, JH., et al. 2018. Korean J Physiol Pharmacol. 22: 331-341. PMID: 29719455
- QX-314 inhibits acid-induced activation of esophageal nociceptive C fiber neurons. | Hu, Y., et al. 2019. Neurogastroenterol Motil. 31: e13543. PMID: 30663188
- Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. | Klasfauseweh, T., et al. 2022. Eur J Pharmacol. 925: 175013. PMID: 35537491
- Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances. | Llinás, R. and Yarom, Y. 1981. J Physiol. 315: 549-67. PMID: 6273544
- Effects of local anesthetic QX-314 on the membrane properties of hippocampal pyramidal neurons. | Connors, BW. and Prince, DA. 1982. J Pharmacol Exp Ther. 220: 476-81. PMID: 6278125
- Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel. | Qu, Y., et al. 1995. Proc Natl Acad Sci U S A. 92: 11839-43. PMID: 8524860
- QX-314 inhibits ectopic nerve activity associated with neuropathic pain. | Omana-Zapata, I., et al. 1997. Brain Res. 771: 228-37. PMID: 9401743
- Local anesthetic block of batrachotoxin-resistant muscle Na+ channels. | Wang, GK., et al. 1998. Mol Pharmacol. 54: 389-96. PMID: 9687581
Inhibitor of:
HIV-1 Nef, RIC-3, and Sodium Channel Protein.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
QX-314, 100 mg | sc-3579 | 100 mg | $120.00 | |||
QX-314, 500 mg | sc-3579A | 500 mg | $416.00 | |||
QX-314, 1 g | sc-3579B | 1 g | $756.00 | |||
QX-314, 2.5 g | sc-3579C | 2.5 g | $1248.00 |