Molecular structure of Quizartinib, Free Base, CAS Number: 950769-58-1
Quizartinib, Free Base (CAS 950769-58-1)
Alternate Names:
AC-220
Application:
Quizartinib, Free Base is an Flt-3/Flk-2 inhibitor
CAS Number:
950769-58-1
Purity:
≥98%
Molecular Weight:
560.67
Molecular Formula:
C29H32N6O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quizartinib, Free Base, is an fms-related tyrosine kinase 3 (FLT3) receptor tyrosine kinase inhibitor. In binding assays, quizartinib has demonstrated a high affinity for FLT3 (Kd = 1.6 nM). in vitro assays examining FLT3 internal tandem duplicate mutations and wild-type FLT3 demonstrate the ability of quizartinib to inhibit FLT3 autophosphorylation (IC50 = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3). Quizartinib, Free Base, has also been shown to inhibit the growth of human leukemia cell line MV4-11 (IC50 = 0.56 nM) and A375 cells (IC50 > 10,000 nM).
Quizartinib, Free Base (CAS 950769-58-1) References
- AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). | Zarrinkar, PP., et al. 2009. Blood. 114: 2984-92. PMID: 19654408
- FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. | Pratz, KW., et al. 2010. Blood. 115: 1425-32. PMID: 20007803
- FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo. | Sato, T., et al. 2011. Blood. 117: 3286-93. PMID: 21263155
Inhibitor of:
2900053A13Rik, Flt-3/Flk-2, FSHR, Olr1125, Olr665, and SCF.Activator of:
FLTR3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quizartinib, Free Base, 1 mg | sc-396767 | 1 mg | $68.00 | |||
Quizartinib, Free Base, 5 mg | sc-396767A | 5 mg | $150.00 |