Molecular structure of Quinine Dihydrochloride, CAS Number: 60-93-5
Quinine Dihydrochloride (CAS 60-93-5)
Alternate Names:
(8α,9R)-6-Methoxycinchonan-9-ol Dihydrochloride
Application:
Quinine Dihydrochloride is an alkaloid
CAS Number:
60-93-5
Molecular Weight:
397.34
Molecular Formula:
C20H26Cl2N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quinine Dihydrochloride functions as an inhibitor of the hemozoin biocrystallization process in Plasmodium falciparum, the parasite responsible for causing malaria. Quinine Dihydrochloride exerts its mechanism of action by binding to the heme molecules produced by the parasite during hemoglobin degradation. By doing so, Quinine Dihydrochloride interferes with the formation of hemozoin, leading to the accumulation of toxic heme molecules within the parasite.
Quinine Dihydrochloride (CAS 60-93-5) References
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- Transferrin-conjugated solid lipid nanoparticles for enhanced delivery of quinine dihydrochloride to the brain. | Gupta, Y., et al. 2007. J Pharm Pharmacol. 59: 935-40. PMID: 17637187
- Ventricular fibrillation in a 5-year-old child on therapeutic dose of quinine dihydrochloride infusion for acute malaria. | Busari, O. and Busari, O. 2008. J Natl Med Assoc. 100: 945-7. PMID: 18717145
- Quinine is bactericidal. | Kharal, SA., et al. 2009. J Pak Med Assoc. 59: 208-12. PMID: 19402279
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- Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers. | Davis, TM., et al. 1990. Br J Clin Pharmacol. 30: 397-403. PMID: 2223418
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- Drug monitoring of quinine by HPLC in cerebral malaria with acute renal failure treated by haemofiltration. | Franke, U., et al. 1987. Eur J Clin Pharmacol. 33: 293-6. PMID: 3319649
- Quinine loading dose in cerebral malaria. | White, NJ., et al. 1983. Am J Trop Med Hyg. 32: 1-5. PMID: 6337514
- Quinine disposition kinetics. | White, NJ., et al. 1983. Br J Clin Pharmacol. 16: 399-403. PMID: 6626434
- Ototoxic reactions of quinine in healthy persons and patients with Plasmodium falciparum infection. | Tange, RA., et al. 1997. Auris Nasus Larynx. 24: 131-6. PMID: 9134134
- Quinine pharmacokinetics: ototoxic and cardiotoxic effects in healthy Caucasian subjects and in patients with falciparum malaria. | Claessen, FA., et al. 1998. Trop Med Int Health. 3: 482-9. PMID: 9657511
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quinine Dihydrochloride, 1 g | sc-212618 | 1 g | $340.00 |