Quinidine Antibody (503): sc-66078

Quinidine Antibody (503) is a mouse monoclonal IgG1 antibody that detects Quinidine in non-species reactive samples through enzyme-linked immunosorbent assay (ELISA). Quinidine is a class I antiarrhythmic agent derived from the bark of the cinchona tree, primarily known for its role in managing cardiac arrhythmias. Quinidine functions by blocking fast inward sodium currents, which decreases the phase 0 depolarization of the cardiac action potential and prolongs the QT interval on the electrocardiogram, making Quinidine crucial for maintaining normal heart rhythm. Additionally, Quinidine interacts with various ion channels, including sodium and potassium channels, which are essential for cardiac excitability and conduction. Quinidine′s ability to inhibit the cytochrome P450 enzyme 2D6 is significant, as this inhibition can lead to increased blood levels of other medications, such as lidocaine and certain antidepressants, thereby necessitating careful monitoring in clinical settings. With a molecular weight of 324.417 g/mol and a half-life of six to eight hours, Quinidine is metabolized in the liver, highlighting the importance of understanding Quinidine′s pharmacokinetics for effective therapeutic use. Anti-Quinidine antibody (503) is an invaluable tool for researchers studying the pharmacological effects and interactions of this important antiarrhythmic agent.