Molecular structure of Quinethazone, CAS Number: 73-49-4
Quinethazone (CAS 73-49-4)
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Alternate Names:
2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxoquinazoline-6-sulfonamide; 2-Ethyl-7-chloro-2,3-dihydro-4(1H)-quinazolone-6-sulfonamide; Aquamox; CL 36010; Hydromox; Idrokin; Quimethazin; Quinethazon; Quinethazonum; 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide; 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-sulfamoylquinazoline; 7-Chloro-2-ethyl-6-sulfamyl-1,2,3,4-tetrahydro-4-quinazolinone
CAS Number:
73-49-4
Molecular Weight:
289.74
Molecular Formula:
C10H12ClN3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quinethazone, also known as hydromox or chinethazonum, is an organic compound belonging to the class of quinazolines. It acts as a long-acting, thiazide-like diuretic by inhibiting active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, which leads to an increase in the excretion of sodium, chloride, and water. As a result, it is detected in biofluids such as urine and blood. Quinethazone is slightly soluble in water and is weakly acidic. It is primarily located in the cytoplasm of cells and can be converted into quinethazone by the enzyme solute carrier family 22 member 6. In addition, thiazides like quinethazone also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide-sensitive sodium-chloride transporter, leading to an increase in potassium excretion via the sodium-potassium exchange mechanism.
Quinethazone (CAS 73-49-4) References
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- Comparison of Chemical Composition between Kuromoji (Lindera umbellata) Essential Oil and Hydrosol and Determination of the Deodorizing Effect. | Nanashima, N., et al. 2020. Molecules. 25: PMID: 32933154
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Inhibitor of:
Na+ CP type XIα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quinethazone, 2.5 mg | sc-477155 | 2.5 mg | $480.00 |