Quinaprilat is the active metabolite of Quinapril and a ACE (angiotensin converting enzyme) inhibitor. This compound prevents the catalyzed conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, and by preventing its formation, vasodilation occurs along with increased capillary blood volume.
Maurer, H., et al.: Ther. Drug. Monit., 20, 706 (1998), Yamada, S., et al.: Biol. Pharm. Bull., 26, 872 (2003),
Soluble in methanol.
Store at 4° C
~674.5° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.61 (Predicted)
α20/D +19.5°±3.5°, c = 1 in methanol
ACE: IC50 = 2.8 nM (human)
pKa: 2.19 (Predicted), pKb: 7.67 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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