Molecular structure of Quinaprilat, CAS Number: 82768-85-2
Quinaprilat (CAS 82768-85-2)
Alternate Names:
USP Quinapril Related Compound B
Application:
Quinaprilat is a metabolite of Quinapril that acts as an ACE inhibitor
CAS Number:
82768-85-2
Molecular Weight:
410.46
Molecular Formula:
C23H26N2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quinaprilat is the active metabolite of Quinapril, an ACE (angiotensin converting enzyme) inhibitor. This compound prevents the catalyzed conversion of angiotensin I to angiotensin II. By inhibiting ACE, quinapril reduces the production of angiotensin II. Quinaprilat is a dicarboxylic acid. Understanding the metabolism of compounds like quinapril to their active forms, such as quinaprilat, is essential in biochemistry. This knowledge contributes to advancing our understanding of chemical biology and the optimization of compounds for specific biological actions. Quinaprilat is considered to be a practically insoluble (in water) and relatively neutral molecule. Quinaprilat is involved in the quinapril metabolism pathway and the quinapril action pathway.
Quinaprilat (CAS 82768-85-2) References
- Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytes. | Ma, H., et al. 1999. Jpn J Pharmacol. 79: 17-24. PMID: 10082313
- Quinapril and its metabolite quinaprilat in human milk. | Begg, EJ., et al. 2001. Br J Clin Pharmacol. 51: 478-81. PMID: 11422007
- Quinaprilat during cardioplegic arrest in the rabbit to prevent ischemia-reperfusion injury. | Korn, P., et al. 2002. J Thorac Cardiovasc Surg. 124: 352-60. PMID: 12167796
- Protective effects of quinaprilat and trandolaprilat, active metabolites of quinapril and trandolapril, on hemolysis induced by lysophosphatidylcholine in human erythrocytes. | Hayase, N., et al. 2003. Biol Pharm Bull. 26: 712-6. PMID: 12736518
- Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits. | Chen, X., et al. 2003. J Cardiovasc Pharmacol. 41: 938-45. PMID: 12775974
- Elimination kinetics of quinaprilat and perindoprilat in hypertensive patients with renal failure on haemodialysis. | Yamada, S., et al. 2003. Biol Pharm Bull. 26: 872-5. PMID: 12808303
- Quinaprilat increases total body vascular compliance in rats with myocardial infarction. | Chien, Y., et al. 1992. J Cardiovasc Pharmacol. 19: 430-4. PMID: 1378125
- Determination of quinapril and quinaprilat in human plasma by ultraperformance liquid chromatography-electrospray ionization mass spectrometry. | Dasandi, B., et al. 2009. Biomed Chromatogr. 23: 492-8. PMID: 19016233
- Quinaprilat-eluting stents do not attenuate intimal thickening following stenting in porcine coronary arteries. | van Beusekom, HM., et al. 2009. Atherosclerosis. 205: 120-5. PMID: 19135197
- Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application. | Kieback, AG., et al. 2009. Expert Opin Drug Metab Toxicol. 5: 1337-47. PMID: 19761414
- Determination of quinapril and quinaprilat by high-performance liquid chromatography with radiochemical detection, coupled to liquid scintillation counting spectrometry. | Kugler, AR., et al. 1995. J Chromatogr B Biomed Appl. 666: 360-7. PMID: 7633615
- Reabsorption and metabolism of quinapril and quinaprilat in rat kidney: in vivo micropuncture studies. | Smith, DE., et al. 1995. J Pharm Sci. 84: 1147-50. PMID: 8801325
- Disposition of quinapril and quinaprilat in the isolated perfused rat kidney. | Kugler, AR., et al. 1995. J Pharmacokinet Biopharm. 23: 287-305. PMID: 8834197
- Screening for the detection of angiotensin-converting enzyme inhibitors, their metabolites, and AT II receptor antagonists. | Maurer, HH., et al. 1998. Ther Drug Monit. 20: 706-13. PMID: 9853992
- Electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusion. | Fujinaga, H., et al. 1998. Coron Artery Dis. 9: 697-701. PMID: 9894622
Inhibitor of:
ACE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quinaprilat, 10 mg | sc-208193 | 10 mg | $418.00 | |||
Quinaprilat, 25 mg | sc-208193A | 25 mg | $510.00 | |||
Quinaprilat, 100 mg | sc-208193B | 100 mg | $1408.00 |