Quinaprilat (CAS 82768-85-2)

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Alternate Names: USP Quinapril Related Compound B

Application: Quinaprilat is a metabolite of Quinapril that acts as an ACE inhibitor

CAS Number: 82768-85-2

Molecular Weight: 410.46

Molecular Formula: C₂₃H₂₆N₂O₅

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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Quinaprilat is the active metabolite of Quinapril and a ACE (angiotensin converting enzyme) inhibitor. This compound prevents the catalyzed conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, and by preventing its formation, vasodilation occurs along with increased capillary blood volume.

References

Maurer, H., et al.: Ther. Drug. Monit., 20, 706 (1998), Yamada, S., et al.: Biol. Pharm. Bull., 26, 872 (2003),

Physical State :

Solid

Solubility :

Soluble in methanol.

Storage :

Store at 4° C

Melting Point :

144-146° C

Boiling Point :

~674.5° C at 760 mmHg (Predicted)

Density :

~1.3 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.61 (Predicted)

Optical Activity :

α20/D +19.5°±3.5°, c = 1 in methanol

IC50 :

ACE: IC₅₀ = 2.8 nM (human)

pK Values :

pK_a: 2.19 (Predicted), pK_b: 7.67 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

107994

MDL Number :

MFCD00865778

SMILES :

C[[email protected]@H](C(=O)N1CC2=CC=CC=C2C[[email protected]]1C(=O)O)N[[email protected]@H](CCC3=CC=CC=C3)C(=O)O

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Certificate of Analysis

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