Molecular structure of Quinapril Hydrochloride, CAS Number: 82586-55-8
Quinapril Hydrochloride (CAS 82586-55-8)
Alternate Names:
Accupril; Accuprin; Acequin; Korec; Quinazil; Acuitel; Lidaltrin; Ectren; Conan
Application:
Quinapril Hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor
CAS Number:
82586-55-8
Purity:
≥97%
Molecular Weight:
474.98
Molecular Formula:
C25H30N2O5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quinapril hydrochloride (Accupril) is an ACE angiotensin-converting enzyme) inhibitor with a Ki of 20 μM. Quinapril is a prodrug that is converted to its active metabolite, quinaprilat. Quinapril′s target, ACE, catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a potent vasoconstrictor and thus preventing its formation causes vasodilation and an increased capillary blood volume.
Quinapril Hydrochloride (CAS 82586-55-8) References
- Physical characteristics and chemical degradation of amorphous quinapril hydrochloride. | Guo, Y., et al. 2000. J Pharm Sci. 89: 128-43. PMID: 10664545
- Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders. | Culy, CR. and Jarvis, B. 2002. Drugs. 62: 339-85. PMID: 11817979
- Effects of quinapril on myocardial function, ventricular remodeling and cardiac cytokine expression in congestive heart failure in the rat. | We, GC., et al. 2002. Cardiovasc Drugs Ther. 16: 29-36. PMID: 12085975
- Ischemia Management with Accupril post bypass Graft via Inhibition of angiotensin coNverting enzyme (IMAGINE): a multicentre randomized trial - design and rationale. | Warnica, JW., et al. 2002. Can J Cardiol. 18: 1191-200. PMID: 12464983
- The stability of quinapril hydrochloride--a mixture of amorphous and crystalline forms (QHCl-AC)--in solid phase. | Stanisz, B. 2003. Acta Pol Pharm. 60: 443-9. PMID: 15080591
- Comparative pharmacokinetics of captopril, enalapril, and quinapril. | Vertes, V. and Haynie, R. 1992. Am J Cardiol. 69: 8C-16C. PMID: 1546641
- The influence of pharmaceutical excipients on quinapril hydrochloride stability. | Stanisz, B. 2005. Acta Pol Pharm. 62: 189-93. PMID: 16193811
- Effect of the pH grade of silicates on chemical stability of coground amorphous quinapril hydrochloride and its stabilization using pH-modifiers. | Hailu, SA. and Bogner, RH. 2009. J Pharm Sci. 98: 3358-72. PMID: 19363809
- Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors. | Hausin, RJ. and Codding, PW. 1991. J Med Chem. 34: 511-7. PMID: 1995872
- Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase. | Stanisz, B., et al. 2010. Acta Pol Pharm. 67: 99-102. PMID: 20210086
- Stabilization of quinapril by incorporating hydrogen bonding interactions. | Roy, BN., et al. 2009. Indian J Pharm Sci. 71: 395-405. PMID: 20502545
- A novel electrochemiluminescence sensor coupled with capillary electrophoresis for simultaneous determination of quinapril hydrochloride and its metabolite quinaprilat hydrochloride in human plasma. | Sun, S., et al. 2018. Talanta. 179: 213-220. PMID: 29310224
- Preclinical toxicology studies with the angiotensin-converting enzyme inhibitor quinapril hydrochloride (Accupril). | McGuire, EJ., et al. 1996. J Toxicol Sci. 21: 207-14. PMID: 8959644
Inhibitor of:
ACE, Ace3, AGT1, Angiotensin, DGCR14, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quinapril Hydrochloride, 100 mg | sc-205829 | 100 mg | $150.00 | |||
Quinapril Hydrochloride, 500 mg | sc-205829A | 500 mg | $450.00 |