Quinapril hydrochloride (Accupril) is an ACE angiotensin-converting enzyme) inhibitor with a Ki of 20 μM. Quinapril is a prodrug that is converted to its active metabolite, quinaprilat. Quinapril's target, ACE, catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a potent vasoconstrictor and thus preventing its formation causes vasodilation and an increased capillary blood volume.
Warnica JW, Gilst WV, Baillot R, Johnstone D, Block P et al. Can J Cardiol. 18:1191-200 (2002). We GC, Siroi MG, QuR, Liu P, Roulea JL. Cardiovasc Drugs Ther. 16:29-36 (2002). Culy CR, Jarvis B. Drugs. 62:339-85 (2002).