Quinapril Hydrochloride CAS: 82586-55-8
MF: C25H30N2O5•HCl
MW: 474.98
An angiotensin-converting enzyme (ACE) inhibitor.

Quinapril Hydrochloride (CAS 82586-55-8)

Quinapril Hydrochloride | CAS 82586-55-8 is rated 5.0 out of 5 by 1.
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Alternate Names: Accupril; Accuprin; Acequin; Korec; Quinazil; Acuitel; Lidaltrin; Ectren; Conan
Application: Quinapril Hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor
CAS Number: 82586-55-8
Purity: ≥97%
Molecular Weight: 474.98
Molecular Formula: C25H30N2O5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Quinapril hydrochloride (Accupril) is an ACE angiotensin-converting enzyme) inhibitor with a Ki of 20 μM. Quinapril is a prodrug that is converted to its active metabolite, quinaprilat. Quinapril's target, ACE, catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a potent vasoconstrictor and thus preventing its formation causes vasodilation and an increased capillary blood volume.


References

Warnica JW, Gilst WV, Baillot R, Johnstone D, Block P et al. Can J Cardiol. 18:1191-200 (2002). We GC, Siroi MG, QuR, Liu P, Roulea JL. Cardiovasc Drugs Ther. 16:29-36 (2002). Culy CR, Jarvis B. Drugs. 62:339-85 (2002).

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (95 mg/ml at 25° C), ethanol (95 mg/ml at 25° C), and DMSO (18 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
120-130° C (lit.)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +14.5°, c = 1.2 in ethanol
IC50 :
ACE: IC50 = 8.3 nM (human); Angiotensin-converting enzyme: IC50 = 4008 nM (rabbit)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
NW7176000
PubChem CID :
Merck Index :
14: 8051
MDL Number :
MFCD00889215
Beilstein Registry :
5699760
SMILES :
CCOC(=O)[[email protected]](CCC1=CC=CC=C1)N[[email protected]@H](C)C(=O)N2CC3=CC=CC=C3C[[email protected]]2C(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Watson Watson, AM. et al. (PubMed 24945577) reported that Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice. -SCBT Publication Review
Date published: 2015-03-16
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