Quetiapine Sulfoxide (CAS 329216-63-9)
QUICK LINKS
Quetiapine sulfoxide is a metabolite of quetiapine, resulting from the oxidation of the sulfur atom in the quetiapine molecule to form a sulfoxide group. Quetiapine acts as an agonist of 5-HT receptors and an antagonist of dopamine receptors. In the field of environmental chemistry, the study of metabolites like quetiapine sulfoxide is important for understanding the fate and impact of compounds in the environment. Analytical chemistry benefits from the study of quetiapine sulfoxide in developing sensitive and specific methods for detecting and quantifying compounds and their metabolites in biological and environmental samples. Advanced analytical techniques, such as liquid chromatography-mass spectrometry (LC-MS), are used to monitor the presence of these compounds in water, soil, and tissue samples.
Quetiapine Sulfoxide (CAS 329216-63-9) References
- Multiple dose pharmacokinetics of quetiapine and some of its metabolites in Chinese suffering from schizophrenia. | Li, KY., et al. 2004. Acta Pharmacol Sin. 25: 390-4. PMID: 15000896
- Quetiapine serum concentrations in psychiatric patients: the influence of comedication. | Hasselstrøm, J. and Linnet, K. 2004. Ther Drug Monit. 26: 486-91. PMID: 15385830
- Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. | Grimm, SW., et al. 2006. Br J Clin Pharmacol. 61: 58-69. PMID: 16390352
- In vitro studies on quetiapine metabolism using the substrate depletion approach with focus on drug-drug interactions. | Hasselstrøm, J. and Linnet, K. 2006. Drug Metabol Drug Interact. 21: 187-211. PMID: 16841513
- Ultra-performance liquid chromatography-tandem mass spectrometry for the determination of atypical antipsychotics and some metabolites in in vitro samples. | Li, KY., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 850: 581-5. PMID: 17257911
- Steady-state pharmacokinetic, safety, and tolerability profiles of quetiapine, norquetiapine, and other quetiapine metabolites in pediatric and adult patients with psychotic disorders. | Winter, HR., et al. 2008. J Child Adolesc Psychopharmacol. 18: 81-98. PMID: 18294091
- Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. | Bakken, GV., et al. 2009. Drug Metab Dispos. 37: 254-8. PMID: 19022943
- Development and validation of an LC-MS/MS method for the determination of quetiapine and four related metabolites in human plasma. | Davis, PC., et al. 2010. J Pharm Biomed Anal. 51: 1113-9. PMID: 20022726
- Measurement of quetiapine and four quetiapine metabolites in human plasma by LC-MS/MS. | Fisher, DS., et al. 2012. Biomed Chromatogr. 26: 1125-32. PMID: 22241669
- Plasma concentrations of quetiapine, N-desalkylquetiapine, o-desalkylquetiapine, 7-hydroxyquetiapine, and quetiapine sulfoxide in relation to quetiapine dose, formulation, and other factors. | Fisher, DS., et al. 2012. Ther Drug Monit. 34: 415-21. PMID: 22777152
- Pharmacokinetic profile of the extended-release formulation of quetiapine fumarate (quetiapine XR): clinical implications. | Bui, K., et al. 2013. Curr Med Res Opin. 29: 813-25. PMID: 23574265
- Determination of plasma concentration reference ranges for oral aripiprazole, olanzapine, and quetiapine. | Korell, J., et al. 2018. Eur J Clin Pharmacol. 74: 593-599. PMID: 29392351
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quetiapine Sulfoxide, 5 mg | sc-212611 | 5 mg | $337.00 |