Molecular structure of Quazinone (Ro 13-6438), CAS Number: 70018-51-8
Quazinone (Ro 13-6438) (CAS 70018-51-8)
Application:
Quazinone (Ro 13-6438) is a phosphodiesterase inhibitor and novel cardiotonic agent with vasodilating properties
CAS Number:
70018-51-8
Molecular Weight:
235.7
Molecular Formula:
C11H10ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quazinone is a chemical compound primarily utilized in the field of biochemistry and cardiovascular research. It is recognized for its function as a phosphodiesterase inhibitor, which has significant implications for the study of intracellular signaling pathways. In particular, Quazinone is of interest in investigations related to the modulation of cyclic nucleotide concentrations within cells. Due to its action on phosphodiesterases, it is also used in research models to understand the biochemical mechanisms that underpin cardiac function and the body′s response to various stressors. Furthermore, Quazinone′s influence on cyclic AMP levels makes it useful in experiments aiming to dissect the complex cascade of events involved in cardiac responses and energy metabolism.
Quazinone (Ro 13-6438) (CAS 70018-51-8) References
- Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes. | Denis, D. and Riendeau, D. 1999. Eur J Pharmacol. 367: 343-50. PMID: 10079010
- Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells. | Tsuji, F., et al. 1999. Immunol Lett. 68: 275-9. PMID: 10424432
- Mechanism of SNAP potentiating antiproliferative effect of calcitonin gene-related peptide in cultured vascular smooth muscle cells. | Wang, X., et al. 1999. J Mol Cell Cardiol. 31: 1599-606. PMID: 10471344
- Adrenomedullin induces direct (endothelium-independent) vasorelaxations and cyclic adenosine monophosphate elevations that are synergistically enhanced by brain natriuretic peptide in isolated rings of rat thoracic aorta. | Fung, E. and Fiscus, RR. 2003. J Cardiovasc Pharmacol. 41: 849-55. PMID: 12775961
- Allergen challenge alters lymphocyte phosphodiesterase activity in horses with heaves. | Rickards, KJ., et al. 2004. Pulm Pharmacol Ther. 17: 163-72. PMID: 15123226
- Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model. | Fryknäs, M., et al. 2006. J Biomol Screen. 11: 457-68. PMID: 16928983
- Haemodynamic effects of Ro 13-6438, a new inotropic agent with vasodilating properties. | Braun, S., et al. 1986. Drugs Exp Clin Res. 12: 381-4. PMID: 3720522
- Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties. | Eigenmann, R., et al. 1984. J Cardiovasc Pharmacol. 6: 511-9. PMID: 6202980
- Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties. | Holck, M., et al. 1984. J Cardiovasc Pharmacol. 6: 520-30. PMID: 6202981
- Determination of the imidazo quinazoline derivative Ro 13-6438 in biological fluids by high-performance liquid chromatography. | Haefelfinger, P. and Hess, B. 1984. J Chromatogr. 305: 153-61. PMID: 6549616
- Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro. | Taher, A., et al. 1994. World J Urol. 12: 286-91. PMID: 7866426
- Phosphodiesterase isoenzymes in human ureteral smooth muscle: identification, characterization, and functional effects of various phosphodiesterase inhibitors in vitro. | Stief, CG., et al. 1995. Urol Int. 55: 183-9. PMID: 8588263
- Cyclic nucleotide phosphodiesterase in human cavernous smooth muscle. | Taher, A., et al. 1997. World J Urol. 15: 32-5. PMID: 9066092
Inhibitor of:
PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quazinone (Ro 13-6438), 10 mg | sc-201196 | 10 mg | $87.00 | |||
Quazinone (Ro 13-6438), 50 mg | sc-201196A | 50 mg | $335.00 |