Molecular structure of QNZ, CAS Number: 545380-34-5
QNZ (CAS 545380-34-5)
See product citations (12)
Alternate Names:
N4-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine;CAY10470
Application:
QNZ is an inhibitor of the transcription factor NFκB
CAS Number:
545380-34-5
Purity:
>98%
Molecular Weight:
356.42
Molecular Formula:
C22H20N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
QNZ inhibits the activation of the transcription factor NF-kappaB and has been used to investigate NF-kappaB signaling. Improper activation of NF-kappaB has been linked to cancer, immune and inflammatory diseases, and viral infection. Research results suggest that QNZ fully blocks the increase in K currents in rat sensory neurons. QNZ has been used to study colorectal cancer and Schwann cell functioning.
QNZ (CAS 545380-34-5) References
- A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives. | Tobe, M., et al. 2003. Bioorg Med Chem. 11: 3869-78. PMID: 12927847
- Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells. | Choi, S., et al. 2006. J Biol Chem. 281: 12722-8. PMID: 16490783
- Laminin activates NF-kappaB in Schwann cells to enhance neurite outgrowth. | Armstrong, SJ., et al. 2008. Neurosci Lett. 439: 42-6. PMID: 18502047
- NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons. | Yang, RH., et al. 2009. Mol Pain. 5: 26. PMID: 19476648
- 17beta-estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells. | Lai, TY., et al. 2010. Mol Cell Biochem. 342: 63-70. PMID: 20446020
- A novel quinazoline-based analog induces G2/M cell cycle arrest and apoptosis in human A549 lung cancer cells via a ROS-dependent mechanism. | Shi, H., et al. 2017. Biochem Biophys Res Commun. 486: 314-320. PMID: 28302490
- Inhibition of TPPP3 attenuates β-catenin/NF-κB/COX-2 signaling in endometrial stromal cells and impairs decidualization. | Shukla, V., et al. 2019. J Endocrinol. 240: 417-429. PMID: 30667362
- Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo. | Sun, X., et al. 2019. Clin Sci (Lond). 133: 1523-1536. PMID: 31270147
- Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia‑reperfusion rats. | Shi, CX., et al. 2020. Mol Med Rep. 21: 123-130. PMID: 31746402
- QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model. | Al-Gayyar, MMH., et al. 2021. Cytokine. 148: 155710. PMID: 34564023
- USP7 Attenuates Endoplasmic Reticulum Stress and NF-κB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation. | Dong, X., et al. 2022. Oxid Med Cell Longev. 2022: 1835900. PMID: 35432716
- Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway. | He, Y., et al. 2022. Chemosphere. 307: 135662. PMID: 35830933
- QNZ exposure induces development toxicity and mechanisms of hatching inhibition in large-scale loach (Paramisgurnus dabryanus) embryos. | Xia, X., et al. 2023. Ecotoxicol Environ Saf. 253: 114663. PMID: 36805135
Inhibitor of:
κB-Ras1, Abin-3, ANKRD10, C9orf9, CARD 14, CARD 6, CARD 8, CB2, CBWD3, EG623459, FAM75A1, FASTKD5, GSDMC2, HHV-4 LMP-1, HIV vpr, HRT1_Hrt1, HSCARG_NMRAL1, IκB-α, IκB-δ, IκB-ζ, ICEBERG, IFI-202, IKK-i, ITF-1, LOC644684, LOC648149, LOC728654, LOC728741, LOC728792, LOC729594, LOC729730, LOC729801, LRTM1, LURAP1L, LYSMD4, M83, MD-1, Mucin 19, NALP14, NF kappa B, NFκB p50, NFKBIL2, NKRF, Nlrp12, Olfr459, p100, PLAA, RBFOX3/NeuN, RelA, RELL1, SPATA2, TRAF4, TRAFD1, TRIM30A, and VSTM3.Activator of:
ADAM33, BCA3, C16orf62, CCDC75, ITI-H3, LILRC1, and TRUNDD.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
QNZ, 1 mg | sc-200675 | 1 mg | $115.00 |