Molecular structure of Q-VD-OPH, CAS Number: 1135695-98-5
Q-VD-OPH (CAS 1135695-98-5)
See product citations (5)
Alternate Names:
Q-VD-OPH is also known as Pan-Caspase Inhibitor (Fluoromethylketone).
Application:
Q-VD-OPH is a low toxicity broad-spectrum inhibitor of caspase-3, caspase-1, caspase-8 and caspase-9.
CAS Number:
1135695-98-5
Purity:
≥95%
Molecular Weight:
513.8
Molecular Formula:
C26H25F2N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 (IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Q-VD-OPH protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of Q-VD-OPH is not o-methylated.
Q-VD-OPH (CAS 1135695-98-5) References
- Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. | Caserta, TM., et al. 2003. Apoptosis. 8: 345-52. PMID: 12815277
- Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: a role for gender. | Renolleau, S., et al. 2007. J Neurochem. 100: 1062-71. PMID: 17166174
- Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH. | Braun, JS., et al. 2007. Exp Neurol. 206: 183-91. PMID: 17585906
- Q-VD-OPh, a pancaspase inhibitor, reduces trauma-induced apoptosis and improves the recovery of hind-limb function in rats after spinal cord injury. | Colak, A., et al. 2009. Neurocirugia (Astur). 20: 533-40; discussion 540. PMID: 19967318
- Caspase activation in transgenic mice with Alzheimer-like pathology: results from a pilot study utilizing the caspase inhibitor, Q-VD-OPh. | Rohn, TT., et al. 2009. Int J Clin Exp Med. 2: 300-8. PMID: 20057974
- Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes. | Kuželová, K., et al. 2011. J Cell Biochem. 112: 3334-42. PMID: 21751237
- The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells. | Chen-Deutsch, X., et al. 2012. Leuk Res. 36: 884-8. PMID: 22541691
- Delayed, long-term administration of the caspase inhibitor Q-VD-OPh reduced brain injury induced by neonatal hypoxia-ischemia. | Han, W., et al. 2014. Dev Neurosci. 36: 64-72. PMID: 24525800
- Does Caspase-6 Have a Role in Perinatal Brain Injury? | Baburamani, AA., et al. 2015. Dev Neurosci. 37: 321-37. PMID: 25823427
- Memantine and Q-VD-OPh Treatments in Experimental Spinal Cord Injury: Combined Inhibition of Necrosis and Apoptosis. | Aydoseli, A., et al. 2016. Turk Neurosurg. 26: 783-9. PMID: 27438623
- The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques. | Laforge, M., et al. 2018. J Clin Invest. 128: 1627-1640. PMID: 29553486
- NLRP3 Inflammasome Is Involved in Q-VD-OPH Induced Necroptosis Following Cerebral Ischemia-Reperfusion Injury. | Teng, X., et al. 2018. Neurochem Res. 43: 1200-1209. PMID: 29802529
- Cell-Free DNA Release by Mouse Fetal Membranes. | Sawyer, MR., et al. 2019. Reprod Sci. 26: 847-857. PMID: 30572800
- Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections. | Alphonse, MP., et al. 2021. Sci Transl Med. 13: PMID: 34233954
Inhibitor of:
4930539E08Rik, 4932412H11Rik, AIFL, Apoptosis, Apoptosis Repressor with CARD (ARC), BNIP-3, C9orf82, CAAP1, caspase-1, caspase-13, caspase-16, caspase-3, caspase-5, caspase-7, caspase-8, caspase-9, CDSN, CHAC2, Chemical and Peptide Caspase, CPP32 p11, D030016E14Rik, DEDD2, EG623459, EVA1A, FAIM, FLASH, GP2, ICH-1S, ISG20L1, MACHβ1, NBK, p20-ARC, Pdcd-7, Programmed cell death (PDCD), reaper, and TMEM45B.Activator of:
ARFGAP1, caspase-9, GGA1, golgin 84, and TBC1D24.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Q-VD-OPH, 5 mg | sc-222230 | 5 mg | $782.00 |