Molecular structure of Pyrrole-2,3,5-tricarboxylic Acid, CAS Number: 945-32-4
Pyrrole-2,3,5-tricarboxylic Acid (CAS 945-32-4)
Alternate Names:
1H-Pyrrole-2,3,5-tricarboxylic Acid
CAS Number:
945-32-4
Molecular Weight:
199.12
Molecular Formula:
C7H5NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pyrrole-2,3,5-tricarboxylic acid is a cyclic organic compound present in various plants, fungi, and bacteria. Its versatile nature has allowed it to serve as a fluorescent probe for investigating protein structure and dynamics, as well as a catalyst in organic synthesis and a promising target for drug development. Its applications extend to studying enzyme properties, identifying novel therapeutics, and unraveling the mechanisms of existing drugs. Notably, it exhibits inhibitory effects on specific cancer cells, possesses anti-inflammatory properties, and demonstrates antiviral activity.
Pyrrole-2,3,5-tricarboxylic Acid (CAS 945-32-4) References
- A validated LC/MS/MS method for the quantification of pyrrole-2,3,5-tricarboxylic acid (PTCA), a eumelanin specific biomarker, in human skin punch biopsies. | Szekely-Klepser, G., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 826: 31-40. PMID: 16139575
- Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin. | Ito, S. and Wakamatsu, K. 2011. J Eur Acad Dermatol Venereol. 25: 1369-80. PMID: 22077870
- Photodegradation of Eumelanin and Pheomelanin and Its Pathophysiological Implications. | Ito, S., et al. 2018. Photochem Photobiol. 94: 409-420. PMID: 28873228
- PTCA (1H-pyrrole-2,3,5-tricarboxylic acid) as a marker for oxidative hair treatment. | Petzel-Witt, S., et al. 2018. Drug Test Anal. 10: 768-773. PMID: 28940782
- A possible new oxidation marker for hair adulteration: Detection of PTeCA (1H-pyrrole-2,3,4,5-tetracarboxylic acid) in bleached hair. | Eisenbeiss, L., et al. 2020. Drug Test Anal. 12: 230-238. PMID: 31655024
- Endogenous 1-H-Pyrrole-2,3,5-Tricarboxylic Acid (PTCA) in Hair and Its Forensic Applications: A Pilot Study on a Wide Multi-Ethnic Population. | Casati, S., et al. 2021. J Anal Toxicol. 45: 269-276. PMID: 32860709
- PTCA (1-H-Pyrrole-2,3,5-Tricarboxylic Acid) as a Marker for Oxidative Hair Treatment: Distribution, Gender Aspects, Correlation with EtG and Self-Reports. | Casati, S., et al. 2021. J Anal Toxicol. 45: 513-520. PMID: 33027522
- Photobleached Oxidative Degradation of Melanins: Chemical Characterization of Melanins Present in Alpaca Fiber. | Wakamatsu, K., et al. 2021. Photochem Photobiol. 97: 1493-1497. PMID: 34435360
- Identification of black sturgeon caviar pigment as eumelanin. | Panzella, L., et al. 2022. Food Chem. 373: 131474. PMID: 34731814
- 5,6-Dihydroxyindole eumelanin content in human skin with varying degrees of constitutive pigmentation. | Del Bino, S., et al. 2022. Pigment Cell Melanoma Res. 35: 622-626. PMID: 35933709
- Structural Investigation of DHICA Eumelanin Using Density Functional Theory and Classical Molecular Dynamics Simulations. | Soltani, S., et al. 2022. Molecules. 27: PMID: 36500509
- Isolation of oligomers of 5,6-dihydroxyindole-2-carboxylic acid from the eye of the catfish. | Ito, S. and Nicol, JA. 1974. Biochem J. 143: 207-17. PMID: 4464851
- An improved modification of permanganate oxidation of eumelanin that gives a constant yield of pyrrole-2,3,5-tricarboxylic acid. | Ito, S. and Wakamatsu, K. 1994. Pigment Cell Res. 7: 141-4. PMID: 7971746
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyrrole-2,3,5-tricarboxylic Acid, 5 mg | sc-476901 | 5 mg | $210.00 | |||
Pyrrole-2,3,5-tricarboxylic Acid, 50 mg | sc-476901A | 50 mg | $2975.00 |