Molecular structure of Pyropheophorbide-a, CAS Number: 24533-72-0
Pyropheophorbide-a (CAS 24533-72-0)
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Alternate Names:
Pyropheophorbide a
Application:
Pyropheophorbide-a is a naturally occurring porphyrin derivative
CAS Number:
24533-72-0
Molecular Weight:
534.66
Molecular Formula:
C33H34N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pyropheophorbide-a possesses photophysical properties and can be activated by light with a wavelength of 630 nm. It is a natural catabolite that arises from the degradation of chlorophyll a induced by ethylene. The mechanism of action of Pyropheophorbide-a is intricate and involves the generation of reactive oxygen species (ROS) upon light exposure. When Pyropheophorbide-a interacts with light, it absorbs the energy and generates ROS, which subsequently react with cellular components, resulting in cell death. Moreover, Pyropheophorbide-a has demonstrated the ability to induce apoptosis in cancer cells and exhibit inhibitory effects on tumor growth and metastasis.
Pyropheophorbide-a (CAS 24533-72-0) References
- Chlorophyll degradation in a Chlamydomonas reinhardtii mutant: an accumulation of pyropheophorbide a by anaerobiosis. | Doi, M., et al. 2001. Plant Cell Physiol. 42: 469-74. PMID: 11382812
- HPLC determination of pheophorbide a and pyropheophorbide a in dried laver product implicated in food poisoning. | Hwang, DF., et al. 2005. Shokuhin Eiseigaku Zasshi. 46: 45-8. PMID: 16018590
- Boron-containing chlorins and tetraazaporphyrins: synthesis and cell uptake of boronated pyropheophorbide a derivatives. | Ratajski, M., et al. 2006. Anticancer Agents Med Chem. 6: 159-66. PMID: 16529538
- Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses. | Bouslama, L., et al. 2011. J Nat Med. 65: 229-33. PMID: 20835849
- Pyropheophorbide A and c(RGDyK) comodified chitosan-wrapped upconversion nanoparticle for targeted near-infrared photodynamic therapy. | Zhou, A., et al. 2012. Mol Pharm. 9: 1580-9. PMID: 22533630
- Antiviral activity of extracts from Morinda citrifolia leaves and chlorophyll catabolites, pheophorbide a and pyropheophorbide a, against hepatitis C virus. | Ratnoglik, SL., et al. 2014. Microbiol Immunol. 58: 188-94. PMID: 24438164
- Folic Acid-Conjugated Pyropheophorbide a as the Photosensitizer Tested for In Vivo Targeted Photodynamic Therapy. | Wang, J., et al. 2017. J Pharm Sci. 106: 1482-1489. PMID: 28263847
- Synthesis and biological evaluation of 173-dicarboxylethyl-pyropheophorbide-a amide derivatives for photodynamic therapy. | Zhu, W., et al. 2018. Bioorg Med Chem Lett. 28: 2784-2788. PMID: 29279274
- Squalene-PEG: Pyropheophorbide-a nanoconstructs for tumor theranostics. | Adriouach, S., et al. 2019. Nanomedicine. 15: 243-251. PMID: 30304701
- Ultra-small Pyropheophorbide-a Nanodots for Near-infrared Fluorescence/Photoacoustic Imaging-guided Photodynamic Therapy. | Siwawannapong, K., et al. 2020. Theranostics. 10: 62-73. PMID: 31903106
- Tumor microenvironment-responsive PEGylated heparin-pyropheophorbide-a nanoconjugates for photodynamic therapy. | Wu, Y., et al. 2021. Carbohydr Polym. 255: 117490. PMID: 33436250
- CD133 peptide-conjugated pyropheophorbide-a as a novel photosensitizer for targeted photodynamic therapy in colorectal cancer stem cells. | Yan, S., et al. 2021. Biomater Sci. 9: 2020-2031. PMID: 33439161
- Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a and Photofrin® in Different Conditions. | Myrzakhmetov, B., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 33572282
- Anti-adipogenic activities of pheophorbide a and pyropheophorbide a isolated from wild bitter gourd (Momordica charantia L. var. abbreviata Seringe) in vitro. | Liu, YH., et al. 2022. J Sci Food Agric. 102: 6771-6779. PMID: 35638177
- Pyropheophorbide-a/(001) TiO2 Nanocomposites with Enhanced Charge Separation and O2 Adsorption for High-Efficiency Visible-Light Degradation of Ametryn. | Liu, S., et al. 2022. Molecules. 27: PMID: 36080345
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyropheophorbide-a, 10 mg | sc-264178 | 10 mg | $194.00 | |||
Pyropheophorbide-a, 50 mg | sc-264178A | 50 mg | $426.00 |