Pyronaridine Tetraphosphate CAS: 76748-86-2
MF: C29H32ClN5O2•4H3PO4
MW: 910.03
An antimalarial agent.

Pyronaridine Tetraphosphate (CAS 76748-86-2)

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Alternate Names: Malaridine
Application: Pyronaridine Tetraphosphate is an antimalarial agent
CAS Number: 76748-86-2
Purity: ≥98%
Molecular Weight: 910.03
Molecular Formula: C29H32ClN5O24H3PO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Pyronaridine Tetraphosphate is a common antimalarial agent that has been found to enhance the antitumor activity of doxorubicin against multidrug-resistant cancers K562/A02 and MCF-7/ADR.


References

Qi J, Wang S, Liu G et al. Biochem Bioph Res Comm. 319: 1124-1131 (2004). Fu S, Bjorkman A, Wahlin B. Brit J Clin Pharmacol. 22: 93-96 (1986).

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water, and very sparingly soluble in ethanol.
Storage :
Store at room temperature
Melting Point :
233-236° C
Boiling Point :
1192.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 0.8 nM; Plasmodium vivax: IC50 = 2.4 nM; Plasmodium malariae: IC50 = 4.1 nM; Jurkat: IC50 = 4 µM (human); IAP: IC50 = 5.61 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
SK4920000
PubChem CID :
5488630
Merck Index :
14: 8005
MDL Number :
MFCD05863545
SMILES :
COC1=CC=C2C(=C(C3=C(N2)C=C(C=C3)Cl)N=C4C=C(C(=O)C(=C4)CN5CCCC5)CN6CCCC6)N1.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O

Download SDS (MSDS)

Certificate of Analysis

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Pyronaridine Tetraphosphate (CAS 76748-86-2)  Product Citations

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Citations 1 to 1 of 1 total

PMID: # 30290222  Tomilov, A.|Allen, S.|Hui, CK.|Bettaieb, A.|Cortopassi, G.| et al. 2018. Pharmacol. Res. 137: 89-103.

Citations 1 to 1 of 1 total
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