Date published: 2026-4-23

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Pyronaridine Tetraphosphate (CAS 76748-86-2)

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Alternate Names:
Malaridine
Application:
Pyronaridine Tetraphosphate is an antimalarial agent
CAS Number:
76748-86-2
Purity:
≥98%
Molecular Weight:
910.03
Molecular Formula:
C29H32ClN5O24H3PO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Pyronaridine tetraphosphate is a chemical compound with significant antimalarial properties. In the field of research, it is particularly useful within the realms of parasitology and cellular biology. As a tetraphosphate derivative, it showcases a distinct mechanism of action that involves interference with the nucleic acid synthesis of specific organisms, thereby inhibiting their growth and proliferation. This action is primarily attributed to its ability to bind to the DNA of parasites, resulting in the blockade of replication and transcription processes. Its molecular design also facilitates the exploration of drug-resistance mechanisms and the development of novel strategies to counteract them. In research applications, Pyronaridine Tetraphosphate serves as a pivotal tool for understanding the complex interactions between drugs and parasitic organisms, offering insights into the molecular pathways that govern parasite survival and resistance. This compound′s role extends beyond its immediate biochemical interactions, as it contributes to the broader scientific endeavor of elucidating the intricacies of parasitic life cycles and the identification of potential targets for novel antiparasitic agents.


Pyronaridine Tetraphosphate (CAS 76748-86-2) References

  1. Absorption, distribution, excretion, and pharmacokinetics of 14C-pyronaridine tetraphosphate in male and female Sprague-Dawley rats.  |  Park, SH. and Pradeep, K. 2010. J Biomed Biotechnol. 2010: 590707. PMID: 20379367
  2. Development of a colloidal gold-based lateral flow dipstick immunoassay for rapid qualitative and semi-quantitative analysis of artesunate and dihydroartemisinin.  |  He, L., et al. 2014. Malar J. 13: 127. PMID: 24678609
  3. Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites.  |  Rizk, MA., et al. 2015. PLoS One. 10: e0125276. PMID: 25915529
  4. Large-scale drug screening against Babesia divergens parasite using a fluorescence-based high-throughput screening assay.  |  Rizk, MA., et al. 2016. Vet Parasitol. 227: 93-7. PMID: 27523944
  5. Performance and consistency of a fluorescence-based high-throughput screening assay for use in Babesia drug screening in mice.  |  Rizk, MA., et al. 2017. Sci Rep. 7: 12774. PMID: 29038534
  6. Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance.  |  Rizk, MA., et al. 2018. Infect Drug Resist. 11: 1605-1615. PMID: 30310296
  7. Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection.  |  Lane, TR., et al. 2019. PLoS Negl Trop Dis. 13: e0007890. PMID: 31751347
  8. Closing the empty anti-Babesia gibsoni drug pipeline in vitro using fluorescence-based high throughput screening assay.  |  Rizk, MA., et al. 2020. Parasitol Int. 75: 102054. PMID: 31927139
  9. Myrrh Oil in Vitro Inhibitory Growth on Bovine and Equine Piroplasm Parasites and Babesia microti of Mice.  |  AbouLaila, M., et al. 2020. Pathogens. 9: PMID: 32121352
  10. Repurposing Pyramax®, quinacrine and tilorone as treatments for Ebola virus disease.  |  Lane, TR., et al. 2020. Antiviral Res. 182: 104908. PMID: 32798602
  11. Impact of using pyronaridine tetraphosphate- based combination therapy in the treatment of babesiosis caused by Babesia bovis, B. caballi, and B. gibsoni in vitro and B. microti in mice.  |  El-Sayed, SAE., et al. 2021. Parasitol Int. 81: 102260. PMID: 33264674
  12. Diminazene aceturate and imidocarb dipropionate-based combination therapy for babesiosis - a new paradigm.  |  Rizk, MA., et al. 2023. Ticks Tick Borne Dis. 14: 102141. PMID: 36812788

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pyronaridine Tetraphosphate, 100 mg

sc-205828
100 mg
$214.00

Pyronaridine Tetraphosphate, 250 mg

sc-205828A
250 mg
$270.00