Pyrithiamine hydrobromide (CAS 534-64-5)

Pyrithiamine hydrobromide, also known as Neopyrithiamine, is a water-soluble Thiamine analog, a vitamin found in both plants and animals. It serves as an essential cofactor for numerous enzymes involved in carbohydrate metabolism, supporting normal growth, development, and proper functioning of the nervous system. As a member of the B-complex vitamin family, which aids in energy release from food and prevents the growth of organisms relying on intact thiamine, Pyrithiamine hydrobromide exhibits notable properties. In growth media, Pyrithiamine hydrobromide effectively inhibits the growth of bacterial and fungal species when present at a pyrithiamine:thiamine ratio of 10:1. Furthermore, in mice, a dietary ratio of 3:1 induces symptoms resembling thiamine deficiency. Additionally, Pyrithiamine hydrobromide demonstrates a dose-dependent inhibition of cocarboxylase formation from thiamine in chicken blood. These unique characteristics contribute to Pyrithiamine hydrobromide′s significance as a research tool in studying metabolic pathways and biochemical functions. Its applications include investigating the impact of Pyrithiamine hydrobromide deficiency on health and development, exploring its role in gene expression regulation, unraveling its involvement in mitochondrial metabolism, and assessing its potential link to cancer development. Notably, Pyrithiamine hydrobromide acts as an indispensable cofactor for enzymes in carbohydrate metabolism, especially transketolase. Moreover, it plays a vital role in energy release from food and influences the synthesis of neurotransmitters like dopamine and acetylcholine, for proper nervous system function.