Molecular structure of Pyripyropene A, CAS Number: 147444-03-9
Pyripyropene A (CAS 147444-03-9)
Alternate Names:
PPPA
Application:
Pyripyropene A is a highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2)
CAS Number:
147444-03-9
Purity:
≥85%
Molecular Weight:
583.6
Molecular Formula:
C31H37NO10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pyripyropropene A is a naturally occurring compound that can be found in Aspergillus fumigatus FO-1289. It functions as a potent and selective inhibitor of acyl-coenzyme A: cholesterol acetyltransferase 2 (ACAT2). Pyripyropene A has been studied for its potential applications in agriculture and environmental management, particularly in controlling pests and insects that are harmful to crops. Its ability to interfere with specific biochemical pathways in insects suggests that it could be used as a lead compound for developing new types of insecticides that are more targeted and environmentally friendly than some currently available options.
Pyripyropene A (CAS 147444-03-9) References
- Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation. | Cho, KH., et al. 2003. Biochem Biophys Res Commun. 309: 864-72. PMID: 13679053
- Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness. | Lada, AT., et al. 2004. J Lipid Res. 45: 378-86. PMID: 14617738
- ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. | Parini, P., et al. 2004. Circulation. 110: 2017-23. PMID: 15451793
- Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A. | Justicia, J., et al. 2005. J Org Chem. 70: 8265-72. PMID: 16209566
- Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites. | Sunazuka, T. and Omura, S. 2005. Chem Rev. 105: 4559-80. PMID: 16351054
- Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms. | Tomoda, H. and Omura, S. 2007. Pharmacol Ther. 115: 375-89. PMID: 17614133
- New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models. | Ohshiro, T., et al. 2015. J Pharmacol Exp Ther. 355: 299-307. PMID: 26338984
- Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening. | Horikoshi, R., et al. 2017. J Antibiot (Tokyo). 70: 272-276. PMID: 28074053
- Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors. | Ohtawa, M., et al. 2018. ChemMedChem. 13: 411-421. PMID: 29323466
- Insecticidal properties of pyripyropene A, a microbial secondary metabolite, against agricultural pests. | Horikoshi, R., et al. 2018. J Pestic Sci. 43: 266-271. PMID: 30479548
- Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties. | Tomoda, H., et al. 1994. J Antibiot (Tokyo). 47: 148-53. PMID: 8150709
- Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D. | Kim, YK., et al. 1994. J Antibiot (Tokyo). 47: 154-62. PMID: 8150710
- Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. | Omura, S., et al. 1993. J Antibiot (Tokyo). 46: 1168-9. PMID: 8360113
- Aflavinines and other antiinsectan metabolites from the ascostromata of Eupenicillium crustaceum and related species. | Wang, HJ., et al. 1995. Appl Environ Microbiol. 61: 4429-35. PMID: 8534106
Inhibitor of:
ACAT-3, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyripyropene A, 500 µg | sc-202302 | 500 µg | $262.00 |