Molecular structure of Pyridoxal-5-phosphate, CAS Number: 54-47-7
Pyridoxal-5-phosphate (CAS 54-47-7)
Alternate Names:
Codecarboxylase
Application:
Pyridoxal-5-phosphate is a coenzyme for amino acid synthesis
CAS Number:
54-47-7
Purity:
≥98%
Molecular Weight:
247.14
Molecular Formula:
C8H10NO6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pyridoxal-5-phosphate is the biologically active form of vitamin B6 and serves as a coenzyme in various enzymatic reactions in the body, primarily in amino acid metabolism. In research, it is utilized to investigate its role in transamination, decarboxylation, and racemization reactions of amino acids. Pyridoxal-5-phosphate is essential in the study of enzymatic mechanisms where it forms a Schiff base with the amino group of amino acids, facilitating a variety of biochemical transformations. Its involvement in the synthesis of neurotransmitters, such as serotonin and gamma-aminobutyric acid (GABA), also makes it a key compound in neuroscience research. Additionally, Pyridoxal-5-phosphate is used to explore its role in glycogen phosphorylase function, which is important for understanding glucose metabolism and energy production in cells.
Pyridoxal-5-phosphate (CAS 54-47-7) References
- Pyridoxal 5'-phosphate inhibits DNA binding of HNF1. | Oka, T., et al. 2001. Biochim Biophys Acta. 1568: 189-96. PMID: 11786225
- Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states. | Allen, GF., et al. 2010. J Neurochem. 114: 87-96. PMID: 20403077
- Pyridoxal 5'-phosphate (PLP) deficiency might contribute to the onset of type I diabetes. | Rubí, B. 2012. Med Hypotheses. 78: 179-82. PMID: 22088923
- Biomimetic Chirality Sensing with Pyridoxal-5'-phosphate. | Pilicer, SL., et al. 2017. J Am Chem Soc. 139: 1758-1761. PMID: 28128945
- Biochemical and Proteomic Studies of Human Pyridoxal 5'-Phosphate-Binding Protein (PLPBP). | Fux, A. and Sieber, SA. 2020. ACS Chem Biol. 15: 254-261. PMID: 31825581
- Supramolecular Tandem Assay for Pyridoxal-5'-phosphate by the Reporter Pair of Guanidinocalix[5]Arene and Fluorescein. | Yue, YX., et al. 2019. ChemistryOpen. 8: 1437-1440. PMID: 32071829
- Binding of pyridoxal, pyridoxal 5'-phosphate and derived hydrazones to bovine serum albumin in aqueous solution. | Gamov, GA., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 233: 118165. PMID: 32120288
- Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. | Akiyama, T., et al. 2020. Pediatr Neurol. 113: 33-41. PMID: 32980745
- Engineered production of pyridoxal 5'-phosphate in Escherichia coli BL21. | He, M., et al. 2022. Prep Biochem Biotechnol. 52: 498-507. PMID: 34431758
- Membrane-Free Stem Cells and Pyridoxal 5'-Phosphate Synergistically Enhance Cognitive Function in Alzheimer's Disease Mouse Model. | Choi, JM., et al. 2022. Antioxidants (Basel). 11: PMID: 35326251
- Complexation of Gold(III) with Pyridoxal 5'-Phosphate-Derived Hydrazones in Aqueous Solution. | Kuranova, NN., et al. 2022. Molecules. 27: PMID: 36364171
- Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring. | Ding, X., et al. 2023. Environ Sci Ecotechnol. 13: 100224. PMID: 36437888
- KCNQ2 Encephalopathy and Responsiveness to Pyridoxal-5'-Phosphate. | Chow, CK., et al. 2023. J Pediatr Genet. 12: 90-94. PMID: 36684546
- Effects of pyridoxal 5'-phosphate on uterine estrogen receptor. II. Inhibition of estrogen. receptor transformation. | Traish, A., et al. 1980. J Biol Chem. 255: 4068-72. PMID: 7372667
- Vitamin B6 metabolism and diabetes. | Rogers, KS. and Mohan, C. 1994. Biochem Med Metab Biol. 52: 10-7. PMID: 7917462
Inhibitor of:
3-Hydroxybutyrate Dehydrogenase, AGXT2L1, AKR1C21, ALDH18A1, ASPDH, BBOX1, Cephalosporin, DHRS1, HAL, Inhibitors, MCT12, PAOX, PAPST2, PNPO, putrescine extracellular binding protein, and TMEM150C.Activator of:
μ-crystallin, 1110037F02Rik, 17β-HSD4, 2810422O20Rik, 3β-HSD, 4832428D23Rik, 4930524E20Rik, ADH, AFMID, AGAT, AGT1, AGXT, AGXT2, AGXT2L2, ALAS-E, ALAS-H, ALDH1L1, ALDH1L2, ALDH6A1, ALKBH8, Amd2, AMT, ASMTL, AUH, B630005N14Rik, BHMT2, C2orf34, C2orf47, C2orf50, C2orf55, CA XV, CDO, CPF, CPVL, CSAD, cSHMT, CTU1, D2HGDH, DAAO, DDC, Dim1, Doxl2, DPRP1, DTD2, E2F-5, EG629667, GAD-25, GLUD1, GluRS, GLYATL2, GlyT2, Gm853, GOT1L1, GPT2, HAAO, HEC-GlcNAc6ST, HIBADH, HPPD, IDS, JMJD8, KY peptidase, kynureninase, L-serine dehydratase, Legumain, MARS2, MAT Iα, MAT III, METTL10, METTL25, METTL2B, METTL5, METTL8, MFT, MGC42105, MGC50559_4833442J19Rik, MMAB, MPST, MSR, MTRR, NAT-8L, ORMDL1, P2X4, PANK2, PAPSS 1, PGD, PLP, PRMT2, PUS1, PUS7, pyridoxal kinase, QPCTL, SAHH, SAHH-3, SerRSmt, Set1A, SLA/LP, SLC48A1, SPDSY, SPTLC2, SPTLC3, TCIRG1, THTR2, TMEM14A, TNAP, Tomt, TPCN2, Transketolase, TRH-DE, TRMT112, Trmt2b, TRMT6, Trp E, TS, TSTD1, TUSC3, TYW1, TYW1B, TYW4, UBE2CBP, Ubie3, and UST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyridoxal-5-phosphate, 5 g | sc-205825 | 5 g | $102.00 |