Pyridoclax (CAS 1651890-44-6)
Alternate Names:
MR-29072
CAS Number:
1651890-44-6
Molecular Weight:
426.51
Molecular Formula:
C29H22N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Pyridoclax (CAS 1651890-44-6) References
- First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. | Gloaguen, C., et al. 2015. J Med Chem. 58: 1644-68. PMID: 25585174
- Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1. | Beekman, AM. and Howell, LA. 2016. ChemMedChem. 11: 802-13. PMID: 26696548
- Survival control of malignant lymphocytes by anti-apoptotic MCL-1. | Fernández-Marrero, Y., et al. 2016. Leukemia. 30: 2152-2159. PMID: 27479182
- Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. | Groo, AC., et al. 2017. Eur J Pharm Sci. 97: 218-226. PMID: 27916693
- Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode. | Hedir, S., et al. 2018. Eur J Med Chem. 159: 357-380. PMID: 30308410
- Binding mode of Pyridoclax to myeloid cell leukemia-1 (Mcl-1) revealed by nuclear magnetic resonance spectroscopy, docking and molecular dynamics approaches. | Bourafai-Aziez, A., et al. 2020. J Biomol Struct Dyn. 38: 4162-4178. PMID: 31612791
- Br vs. TsO Chemoselective Suzuki–Miyaura Cross‐Coupling Reaction on Nicotinaldehyde Moiety for the Preparation of 2, 3, 5‐Trisubstituted Pyridines. | Hédou, Damien and Anne Sophie Voisin‐Chiret. 2020. European Journal of Organic Chemistry. 2020.24: 3640-3649.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyridoclax, 50 mg | sc-507330 | 50 mg | $630.00 |