Pyrazolylpyrrole ERK Inhibitor CAS: 933786-58-4
MF: C22H17Cl2FN4O2
MW: 459.30
A potent inhibitor of ERK2.

Pyrazolylpyrrole ERK Inhibitor (CAS 933786-58-4)

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Application: Pyrazolylpyrrole ERK Inhibitor is a potent inhibitor of ERK2
CAS Number: 933786-58-4
Purity: >98%
Molecular Weight: 459.30
Molecular Formula: C22H17Cl2FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Pyrazolylpyrrole ERK Inhibitor is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). Inhibits proliferation of Colo205 cells with an IC50 value of 0.54 µM.


References

1 Junttila, M.R., Li, S., Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22 1-12 (2008). 2 Aronov, A.M., Baker, C., Bemis, G.W., et al. Flipped out: Structure-guided of select

Physical State :
Solid
Solubility :
Soluble in 1:1 ethanol:PBS (pH 7.2) (~0.5 mg/ml), ethanol (~ 5 mg/ml), DMSO (~ 1.5 mg/ml), and DMF (~ 2.5 mg/ml).
Storage :
Store at -20° C
IC50 :
Colo205 cells: IC50 = 0.54 µM
Ki Data :
ERK2: Ki= 2 nM; PKA: Ki= 0.39 µM; JNK3: Ki= 4 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1=CC(=CC(=C1)Cl)C2=CNNC2=C3C=C(N=C3)C(=O)NC(CO)C4=CC(=C(C=C4)F)Cl

Download SDS (MSDS)

Certificate of Analysis

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Pyrazolylpyrrole ERK Inhibitor (CAS 933786-58-4)  Product Citations

See how others have used Pyrazolylpyrrole ERK Inhibitor (CAS 933786-58-4). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25695333  Samadani, R. et al. 2015. The Biochemical journal. 467: 425-38.

PMID: # 24509437  Dochi, T. et al. 2014. The Journal of general virology. 95: 1156-66.

Citations 1 to 2 of 2 total

vorrei conoscere la concentrazione da utilizzare nelle cellule in coltura.

Asked by: oriana
Thank you for your inquiry. This product has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols. For additional information, please contact our Technical Service at [email protected]
Answered by: Technical Support Europe
Date published: 2019-02-12
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