Pyrazolylpyrrole ERK Inhibitor is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). Inhibits proliferation of Colo205 cells with an IC50 value of 0.54 µM.
1 Junttila, M.R., Li, S., Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22 1-12 (2008). 2 Aronov, A.M., Baker, C., Bemis, G.W., et al. Flipped out: Structure-guided of select
vorrei conoscere la concentrazione da utilizzare nelle cellule in coltura.
Asked by: oriana
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