Molecular structure of Pyrazolylpyrrole ERK Inhibitor, CAS Number: 933786-58-4
Pyrazolylpyrrole ERK Inhibitor Inhibitor (CAS 933786-58-4)
See product citations (3)
Application:
Pyrazolylpyrrole ERK Inhibitor is a potent inhibitor of ERK2
CAS Number:
933786-58-4
Purity:
>98%
Molecular Weight:
459.30
Molecular Formula:
C22H17Cl2FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Pyrazolylpyrrole ERK Inhibitor is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). Inhibits proliferation of Colo205 cells with an IC50 value of 0.54 µM.
Pyrazolylpyrrole ERK Inhibitor Inhibitor (CAS 933786-58-4) References
- Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. | Aronov, AM., et al. 2007. J Med Chem. 50: 1280-7. PMID: 17300186
- Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling. | Jung, KY., et al. 2013. Org Biomol Chem. 11: 3706-32. PMID: 23624850
- Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf. | Samadani, R., et al. 2015. Biochem J. 467: 425-38. PMID: 25695333
- N-WASP Attenuates Cell Proliferation and Migration through ERK2-Dependent Enhanced Expression of TXNIP. | Chung, YJ., et al. 2022. Biology (Basel). 11: PMID: 35453780
Inhibitor of:
ERK 2, and Ser/Thr Protein Kinase.Activator of:
pro-MCH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyrazolylpyrrole ERK Inhibitor, 500 µg | sc-222229 | 500 µg | $42.00 | |||
Pyrazolylpyrrole ERK Inhibitor, 1 mg | sc-222229A | 1 mg | $80.00 |