Molecular structure of Pyrazole N-Demethyl Sildenafil-d3
Pyrazole N-Demethyl Sildenafil-d3
Application:
Pyrazole N-Demethyl Sildenafil-d3 is a deuterium-labelled derivative of Sildenafil
Molecular Weight:
463.57
Molecular Formula:
C21H25D3N6O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pyrazole N-Demethyl Sildenafil-d3 is a deuterium-labelled derivative of Sildenafil (sc-338584). Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.
Pyrazole N-Demethyl Sildenafil-d3 References
- Chinese proprietary medicine in Singapore: regulatory control of toxic heavy metals and undeclared drugs. | Koh, HL. and Woo, SO. 2000. Drug Saf. 23: 351-62. PMID: 11085343
- Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles. | Seftel, AD. 2004. Clin Cardiol. 27: I14-19. PMID: 15115191
- The role of sildenafil in the treatment of stroke. | Bednar, MM. 2008. Curr Opin Investig Drugs. 9: 754-9. PMID: 18600581
- Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism. | Kato, N., et al. 2009. Dig Dis Sci. 54: 2346-56. PMID: 19101800
- Single-Laboratory Validation Study of a Method for Screening and Identification of Phosphodiesterase Type 5 Inhibitors in Dietary Ingredients and Supplements Using Liquid Chromatography/Quadrupole-Orbital Ion Trap Mass Spectrometry: First Action 2015.12. | Vaclavik, L., et al. 2016. J AOAC Int. 99: 55-72. PMID: 26846459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyrazole N-Demethyl Sildenafil-d3, 1 mg | sc-219672 | 1 mg | $430.00 |