Date published: 2025-11-24

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Pyrazine (CAS 290-37-9)

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CAS Number:
290-37-9
Molecular Weight:
80.09
Molecular Formula:
C4H4N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Pyrazine, a simple yet fascinating heterocyclic aromatic compound, is distinguished by its pair of nitrogen atoms directly opposite each other in its six-membered ring structure. This configuration endows pyrazine with unique electronic properties, making it an indispensable scaffold in the synthesis of more complex molecules for various research applications. In the realm of chemical research, pyrazine serves as a key building block in the design and development of molecules with specific electronic characteristics, such as enhanced conductivity or photoluminescence, making it for advancing materials science. Furthermore, its ability to act as a ligand, forming coordination complexes with metals, has been exploited in the synthesis of novel catalysts and in the study of metal-organic frameworks (MOFs), which are of great interest for their potential applications in gas storage, separation technologies, and catalysis. The role of pyrazine in research extends into the exploration of its derivatives for their potential application in the development of new materials and chemicals that exhibit specific, desirable properties, such as thermal stability and electronic conductivity, highlighting its versatility and significance in scientific exploration and innovation.


Pyrazine (CAS 290-37-9) References

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  3. Alkyl pyrazine synthesis via an open heated bath with variable sugars, ammonia, and various amino acids.  |  Ara, KM., et al. 2017. J Sci Food Agric. 97: 2263-2270. PMID: 27629531
  4. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation.  |  Evans, EL., et al. 2018. Br J Pharmacol. 175: 1744-1759. PMID: 29498036
  5. Enzymatic Cascade in Pseudomonas that Produces Pyrazine from α-Amino Acids.  |  Masuo, S., et al. 2020. Chembiochem. 21: 353-359. PMID: 31322801
  6. New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS-CoV-2.  |  Seliem, IA., et al. 2021. ChemMedChem. 16: 3418-3427. PMID: 34352160
  7. Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery.  |  Huigens, RW., et al. 2022. Molecules. 27: PMID: 35164376
  8. Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties.  |  Mech-Warda, P., et al. 2022. Molecules. 27: PMID: 35744829
  9. Structural Sampling and Solvation Models for the Simulation of Electronic Spectra: Pyrazine as a Case Study.  |  Tsuru, S., et al. 2023. J Chem Theory Comput. 19: 2291-2303. PMID: 36971352
  10. Pharmacological activity and mechanism of pyrazines.  |  Hou, W., et al. 2023. Eur J Med Chem. 258: 115544. PMID: 37300915
  11. Design and Synthesis of Far-Red to Near-Infrared Chromophores with Pyrazine-Based Boron Complexes.  |  Takahashi, H., et al. 2023. Chem Asian J. e202300489. PMID: 37365136
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pyrazine, 5 g

sc-250805
5 g
$22.00

Pyrazine, 10 g

sc-250805A
10 g
$36.00