Molecular structure of Pyrazinamide-d3, CAS Number: 1432059-16-9
Pyrazinamide-d3 (CAS 1432059-16-9)
Application:
Pyrazinamide-d3 is an antibacterial
CAS Number:
1432059-16-9
Molecular Weight:
126.11
Molecular Formula:
C5H2D3N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pyrazinamide-d3 is a deuterium-labeled version of pyrazinamide, a compound traditionally utilized in various applications. The substitution of three hydrogen atoms with deuterium in this analogue enhances its stability and alters its physical properties, which can be beneficial in various analytical applications. This isotopic labeling allows for detailed tracking and analysis of the pyrazinamide′s metabolism and pharmacokinetic properties using techniques such as mass spectrometry. Pyrazinamide-d3 is useful in research studies to better understand the behavior of the parent compound under different physiological conditions.
Pyrazinamide-d3 (CAS 1432059-16-9) References
- Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum. | Lanoix, JP., et al. 2016. Antimicrob Agents Chemother. 60: 735-43. PMID: 26574016
- An improved LC-MS/MS method for the simultaneous determination of pyrazinamide, pyrazinoic acid and 5-hydroxy pyrazinoic acid in human plasma for a pharmacokinetic study. | Shah, PA., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1017-1018: 52-61. PMID: 26945134
- Simultaneous quantification of isoniazid, rifampicin, ethambutol and pyrazinamide by liquid chromatography/tandem mass spectrometry. | Prahl, JB., et al. 2016. APMIS. 124: 1004-1015. PMID: 27546025
- Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation. | Vinnard, C., et al. 2017. PLoS One. 12: e0187624. PMID: 29095954
- Simultaneous analysis of 11 medications for drug resistant TB in small hair samples to quantify adherence and exposure using a validated LC-MS/MS panel. | Gerona, R., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1125: 121729. PMID: 31369929
- Validation and application of a quantitative LC-MS/MS assay for the analysis of first-line anti-tuberculosis drugs, rifabutin and their metabolites in human breast milk. | Zuma, P., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1211: 123489. PMID: 36215877
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyrazinamide-d3, 1 mg | sc-219671 | 1 mg | $312.00 |