Pyochelin I and Pyochelin II
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Pyochelin I and Pyochelin II are two types of iron-chelating siderophores produced by the bacterium Pseudomonas aeruginosa. Siderophores are small molecules that are secreted by bacteria to scavenge iron from the environment, which is an essential nutrient for their growth and survival. Pyochelin I and II are structurally similar molecules composed of a cyclic dipeptide backbone linked to a hydroxamate group. They are important biomarkers and virulence factors of P. aeruginosa, as they allow the bacterium to obtain iron from the host during infection, and they also have immunomodulatory effects. They have been widely used in scientific research as tools to study bacterial physiology and pathogenesis. Some common applications of Pyochelin I and II in research include iron acquisition and metabolism, antibacterial activity, biofilm formation, and pathogenesis.
Pyochelin I and Pyochelin II References
- Isolation and characterization of Burkholderia cenocepacia mutants deficient in pyochelin production: pyochelin biosynthesis is sensitive to sulfur availability. | Farmer, KL. and Thomas, MS. 2004. J Bacteriol. 186: 270-7. PMID: 14702294
- PchC thioesterase optimizes nonribosomal biosynthesis of the peptide siderophore pyochelin in Pseudomonas aeruginosa. | Reimmann, C., et al. 2004. J Bacteriol. 186: 6367-73. PMID: 15375116
- Ferripyochelin uptake genes are involved in pyochelin-mediated signalling in Pseudomonas aeruginosa. | Michel, L., et al. 2007. Microbiology (Reading). 153: 1508-1518. PMID: 17464065
- The pobA gene of Burkholderia cenocepacia encodes a group I Sfp-type phosphopantetheinyltransferase required for biosynthesis of the siderophores ornibactin and pyochelin. | Asghar, AH., et al. 2011. Microbiology (Reading). 157: 349-361. PMID: 20966087
- The role of siderophores in metal homeostasis of members of the genus Burkholderia. | Mathew, A., et al. 2016. Environ Microbiol Rep. 8: 103-9. PMID: 26621188
- Pseudomonas protegens CS1 from the lemon phyllosphere as a candidate for citrus canker biocontrol agent. | Michavila, G., et al. 2017. Plant Biol (Stuttg). 19: 608-617. PMID: 28194866
- Biosynthesis of pyochelin and dihydroaeruginoic acid requires the iron-regulated pchDCBA operon in Pseudomonas aeruginosa. | Serino, L., et al. 1997. J Bacteriol. 179: 248-57. PMID: 8982005
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyochelin I and Pyochelin II, 1 mg | sc-506665 | 1 mg | $356.00 | |||
Pyochelin I and Pyochelin II, 10 mg | sc-506665A | 10 mg | $2529.00 |