PXDN Antibody (2C11): sc-293408

PXDN Antibody (2C11) is a mouse monoclonal IgG2b kappa light chain antibody that detects the PXDN protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PXDN antibody (2C11) is available as the non-conjugated format. PXDN, or peroxidasin homolog, is a significant 1,479 amino acid secreted protein that plays a crucial role in the formation of the extracellular matrix, which is essential for tissue structure and function. PXDN shows predominant expression in the heart, lung, ovary, spleen, intestine, and placenta, while showing lower expression levels in the liver, colon, pancreas, kidney, thymus, skeletal muscle, and prostate. PXDN involvement in the stabilization and remodeling of the extracellular matrix is vital for maintaining tissue integrity and facilitating cellular communication. Structurally, PXDN belongs to the peroxidase family and the XPO subfamily, featuring four immunoglobulin-like C2-type domains, four leucine-rich repeats, one LRRCT domain, one LRRNT domain, and a VWFC domain. PXDN may exist as two alternative isoforms and can form a homotrimer, showcasing a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs typically associated with extracellular matrix proteins. This multifaceted role and structure underscore PXDN significance in various biological processes and potential implications in health and disease.

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PXDN Antibody (2C11) References:

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