PX-478 (CAS 685898-44-6)
Alternate Names:
PX 478 PX478 PX-478 2HCl PX-478 HCl
CAS Number:
685898-44-6
Molecular Weight:
394.10
Molecular Formula:
C13H20Cl4N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PX-478 (CAS 685898-44-6) References
- PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. | Palayoor, ST., et al. 2008. Int J Cancer. 123: 2430-7. PMID: 18729192
- A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor. | Lee, K. and Kim, HM. 2011. Arch Pharm Res. 34: 1583-5. PMID: 22076756
- Effects and Mechanism of Action of PX-478 in Oxygen-Induced Retinopathy in Mice. | Pan, X. and Lv, Y. 2020. Ophthalmic Res. 63: 182-193. PMID: 31955159
- Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. | Hua, X., et al. 2020. Circulation. 142: 384-400. PMID: 32431172
- Hypoxia inducible factor 1α inhibitor PX-478 reduces atherosclerosis in mice. | Villa-Roel, N., et al. 2022. Atherosclerosis. 344: 20-30. PMID: 35121387
- HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes. | Ilegems, E., et al. 2022. Sci Transl Med. 14: eaba9112. PMID: 35353540
- Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation. | Wang, P., et al. 2022. Acta Pharm Sin B. 12: 1899-1912. PMID: 35847503
- HIF1A inhibitor PX-478 reduces pathological stretch-induced calcification and collagen turnover in aortic valve. | Salim, MT., et al. 2022. Front Cardiovasc Med. 9: 1002067. PMID: 36419483
- Autophagy inhibition and ferroptosis activation during atherosclerosis: Hypoxia-inducible factor 1α inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages. | Hu, G., et al. 2023. Biomed Pharmacother. 161: 114333. PMID: 36948130
- PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer. | Panahi Meymandi, AR., et al. 2024. Front Oncol. 14: 1357801. PMID: 38425341
Inhibitor of:
AMPKα1, Arnt 2, CCBE1, DEP-1, E330017A01Rik, H1T2, HID, HIF-1 alpha, HIF-3α, IGFBP3, LOXL4, Mettl7a2-Higd1c, P4HA1, p53CSV, Sox-14, TR4, TSG-6, VHL, ZBRK1, ZBTB7C, and ZNF645.Activator of:
ASCT2, CA IX, ECSCR, HIF-3α, HIGD1B, and Testican-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PX-478, 10 mg | sc-507409 | 10 mg | $175.00 |