Putrescine dihydrochloride CAS: 333-93-7
MF: C4H12N2•2HCl
MW: 161.08
An NMDA agonist.

Putrescine dihydrochloride (CAS 333-93-7)

Putrescine dihydrochloride | CAS 333-93-7 is rated 5.0 out of 5 by 2.
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Alternate Names: 1,4-Diaminobutane • 2HCl; Tetramethylenediamine • 2HCl
Application: Putrescine dihydrochloride is an NMDA agonist
CAS Number: 333-93-7
Purity: ≥98%
Molecular Weight: 161.08
Molecular Formula: C4H12N22HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Putrescine dihydrochloride can bind to the polyamine modulatory site of the NMDA (N-methyl D-aspartate) receptor and potentiate NMDA-induced currents. Polyamines belong to a group of aliphatic amines that are selective and act on different ion channels. Putrescine dihydrocloride is a precursor of spermidine. Putrescine dihydrochloride is an activator of NMDA.


References

1. Volkow, N., et al. 1983. Science. 221: 673-675. PMID: 6603020
2. Sprosen, T.S., et al. 1990. Eur. J. Pharmacol. 179: 477-478. PMID: 1694770
3. Scott, R.H., et al. 1993. Trends Neurosci. 16: 153-160. PMID: 7682349

Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml).
Storage :
Store at 4° C
Melting Point :
280° C (lit.)(dec.)
Refractive Index :
n20D 1.46 (Predicted)
IC50 :
L1210: IC50 = >100 µM (mouse); CHO-MG: IC50 = >100 µM (Cricetulus griseus); CHO: IC50 = >100 µM (Cricetulus griseus); Phosphodiesterase 1: IC50 = >500 µM (Bos taurus); Calf thymus DNA: IC50 = 4.5 mM (Bos taurus)
Ki Data :
MDA-MB-231: Ki= 1.28 µM (human); T47D: Ki= 7.4 µM (human); Ornithine decarboxylase: Ki= 3.3 mM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EJ7280000
PubChem CID :
9532
Merck Index :
14: 7947
MDL Number :
MFCD00012526
EC Number :
206-375-9
Beilstein Registry :
3906680
SMILES :
C(CCN)CN.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Putrescine dihydrochloride (CAS 333-93-7)  Product Citations

See how others have used Putrescine dihydrochloride (CAS 333-93-7). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 32139506  J. Biol. Chem.

PMID: # 31406117  Nat Commun. 10: 3634.

Citations 1 to 2 of 2 total

Hi , Iam researcher from Iraq ,I ask about eligible of international shipping for Putrescine to Iraq. regards

Asked by: wisam
Thank you for your question! To obtain accurate shipping and pricing informationour products, please contact our European Customer Service team. Alternatively, you can contact our local distributor in Iraq, https://www.scbt.com/scbt/resources/distributors.
Answered by: Tech Service
Date published: 2019-06-13
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Rated 5 out of 5 by from Good Service Great customer support team kept me informed on order updates all through the purchase process
Date published: 2019-08-16
Rated 5 out of 5 by from Tao Tao, Y. et al. (PubMed 26082481) reported that peri-ovulatory Putrescine supplementation reduces embryo resorption in older mice. -SCBT Publication Review
Date published: 2015-05-25
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