Purine (CAS 120-73-0)
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Purine serves as a fundamental nucleotide base pivotal in the field of proteomics research, where it underpins the structural framework of nucleic acids, namely DNA and RNA. As a key component, purine, along with its derivatives adenine and guanine, plays a role in the encoding, transcription, and regulation of genetic information. Its structure, characterized by a fused ring compound consisting of a pyrimidine ring joined to an imidazole ring, allows for intricate hydrogen bonding with its complementary pyrimidine bases, cytosine and thymine (or uracil in RNA), facilitating the stable helical structure of DNA and the single-stranded RNA necessary for protein synthesis. Beyond its genetic role, purine nucleotides are integral in cellular signaling and energy transfer processes, notably as precursors to important biomolecules like ATP, GTP, cyclic AMP, and NADH.
Purine (CAS 120-73-0) References
- The purine and pyrimidine composition of the tobacco mosaic virus and the Holmes masked strain. | COOPER, WD. and LORING, HS. 1954. J Biol Chem. 211: 505-15. PMID: 13221558
- Purine and pyrimidine contents of some desoxypentose nucleic acids. | DALY, MM., et al. 1950. J Gen Physiol. 33: 497-510. PMID: 15422104
- Anti-malarial activity of N6-modified purine analogues. | Too, K., et al. 2007. Bioorg Med Chem. 15: 5551-62. PMID: 17548196
- Prediction of elution bandwidth for purine compounds by a retention model in reversed-phase HPLC with linear-gradient elution. | Jin, CH., et al. 2008. J Sep Sci. 31: 23-9. PMID: 18064619
- Resonance-enhanced multiphoton ionisation of purine. | Schneider, M., et al. 2009. Chemphyschem. 10: 634-6. PMID: 19219888
- A class of novel conjugates of substituted purine and Gly-AA-OBzl: synthesis and evaluation of orally analgesic activity. | Kang, G., et al. 2010. Bioorg Med Chem Lett. 20: 6157-60. PMID: 20833035
- Novel developments in metabolic disorders of purine and pyrimidine metabolism and therapeutic applications of their analogs. | Torres, RJ., et al. 2014. Nucleosides Nucleotides Nucleic Acids. 33: 165-73. PMID: 24940665
- 1,3,5-Triazine-based analogues of purine: from isosteres to privileged scaffolds in medicinal chemistry. | Lim, FP. and Dolzhenko, AV. 2014. Eur J Med Chem. 85: 371-90. PMID: 25105925
- Optimization of High Performance Liquid Chromatography Method for Simultaneous Determination of Some Purine and Pyrimidine Bases. | Markelj, J., et al. 2016. Acta Chim Slov. 63: 8-17. PMID: 26970783
- Purine Functional Group Type and Placement Modulate the Interaction with Carbon-Fiber Microelectrodes. | Lim, GN. and Ross, AE. 2019. ACS Sens. 4: 479-487. PMID: 30657307
- Role of purines in regulation of metabolic reprogramming. | Tang, Z., et al. 2019. Purinergic Signal. 15: 423-438. PMID: 31493132
- Metabolic Tools for Identification of New Mutations of Enzymes Engaged in Purine Synthesis Leading to Neurological Impairment. | Krijt, M., et al. 2019. Folia Biol (Praha). 65: 152-157. PMID: 31638562
- Recent updates on purine and pyrimidine metabolism in physiological and pathological settings. | Jordheim, LP. and Peters, GJ. 2020. Nucleosides Nucleotides Nucleic Acids. 39: 1273-1280. PMID: 32182157
- Biogenic Guanine Crystals Are Solid Solutions of Guanine and Other Purine Metabolites. | Pinsk, N., et al. 2022. J Am Chem Soc. 144: 5180-5189. PMID: 35255213
- Determination of total purine and free purine content in milk, soymilk, and enteral nutritional supplements to assist nutritional therapy for hyperuricemia and gout. | Fukuuchi, T., et al. 2022. Nucleosides Nucleotides Nucleic Acids. 41: 1287-1295. PMID: 35767334
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Purine, 1 g | sc-215761 | 1 g | $199.00 |