Punctin/ADAMTSL1 Antibody (PU29Z): sc-74258

Punctin Antibody (PU29Z) is a mouse monoclonal IgG2b antibody that detects the Punctin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Punctin antibody (PU29Z) is available as the non-conjugated format. Punctin, also known as Punctin-1 or ADAMTS-like protein 1 (ADAMTSL-1), is a secreted, glycosylated protein that plays a crucial role in extracellular matrix turnover, which is vital for tissue homeostasis and repair. Punctin (PU29Z) antibody recognizes a protein primarily located in the extracellular matrix of skeletal muscle, where Punctin contributes to structural integrity and matrix function. Punctin is characterized by a unique structure including a signal peptide, four thrombospondin type-1 repeats (TSRs), a cysteine-rich domain, and a spacer region, which collectively facilitate interactions within the extracellular environment. O-fucosylation of the TSR repeats is a significant post-translational modification that regulates Punctin secretion, highlighting the importance of glycosylation in functional activity. Punctin is closely related to the larger ADAMTS-like protein, Punctin-2, and shares similarities with the invertebrate protein papilin. Two isoforms of Punctin exist due to alternative splicing, with isoform 1 representing the full-length mature protein, while isoform 2 is truncated and contains a distinct sequence, underscoring the complexity and regulatory mechanisms governing expression and function.

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Punctin/ADAMTSL1 Antibody (PU29Z) References:

1. Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix.  |  Hirohata, S., et al. 2002. J Biol Chem. 277: 12182-9. PMID: 11805097
2. Regulation of transcripts encoding ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin-like motifs-1) and progesterone receptor by human chorionic gonadotropin in equine preovulatory follicles.  |  Boerboom, D., et al. 2003. J Mol Endocrinol. 31: 473-85. PMID: 14664708
3. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.  |  Hall, NG., et al. 2003. Matrix Biol. 22: 501-10. PMID: 14667842
4. Gene expression profile activated by the chemokine CCL5/RANTES in human neuronal cells.  |  Valerio, A., et al. 2004. J Neurosci Res. 78: 371-82. PMID: 15389840
5. The ADAMTS metalloproteinases.  |  Porter, S., et al. 2005. Biochem J. 386: 15-27. PMID: 15554875
6. The ADAMTS proteases, extracellular matrix, and vascular disease: waking the sleeping giant(s)!  |  Wight, TN. 2005. Arterioscler Thromb Vasc Biol. 25: 12-4. PMID: 15626768
7. Mapping autosomal dominant progressive limb-girdle myopathy with bone fragility to chromosome 9p21-p22: a novel locus for a musculoskeletal syndrome.  |  Watts, GD., et al. 2005. Hum Genet. 118: 508-14. PMID: 16244874
8. Microarray-based DNA methylation profiling: technology and applications.  |  Schumacher, A., et al. 2006. Nucleic Acids Res. 34: 528-42. PMID: 16428248
9. O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily.  |  Wang, LW., et al. 2007. J Biol Chem. 282: 17024-31. PMID: 17395588

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Punctin/ADAMTSL1 Antibody (PU29Z) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Punctin/ADAMTSL1 Antibody (PU29Z) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Punctin/ADAMTSL1 Antibody (PU29Z) Specifications

Alternate Product Name: Punctin

Product Clone Name: PU29Z

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Punctin

Epitope Species: human

Product Reactivity/Detection: Punctin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Punctin/ADAMTSL1 Antibody (PU29Z): N/A